Locus ceruleus somata contain both acetylcholin esterase and norepinephrine: direct histochemical demonstration on the same tissue section

Alberto Albanese, Larry L. Butcher

Research output: Contribution to journalArticle

39 Citations (Scopus)

Abstract

In the same brain section stained first for catecholamines and then for acetylcholinesterase (EC 3.1.1.7), it was found that neuronal somata in locus ceruleus containing norepinephrine also contained the cholinergic degradative enzyme. Cell body shapes were fusiform, pyramidal, round, or oval. Maximum soma extent ranged from 10--40 micrometers, with the proportion of large diameter neurons increasing, and the smaller diameter cells decreasing, from rostral to caudal cerulear levels. Medium-sized neurons were roughly constant throughout the nucleus. Acetylcholinesterase may be associated with cerulear somata and proximal processes containing norepinephrine to inactivate a cholinergic input to that structure.
Original languageEnglish
Pages (from-to)101-104
Number of pages4
JournalNeuroscience Letters
Volume14
Publication statusPublished - 1979

Keywords

  • Acetylcholinesterase
  • Animals
  • Female
  • Histocytochemistry
  • Locus Coeruleus
  • Norepinephrine
  • Rats

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