Living Kidney Donation in a Type 1 Dent's Disease Patient from His Mother

Pietro Manuel Ferraro, Jacopo Romagnoli, Franco Citterio, Giovanni Gambaro, Alessandro Naticchia, Gionata Spagnoletti

Research output: Contribution to journalArticle

1 Citation (Scopus)


Introduction: Dent's disease is a rare X-linked recessive disorder that manifests in childhood or early adulthood and can lead to end-stage renal disease (ESRD). It occurs in males, who are hemizygous. In patients who develop ESRD, a deceased donor kidney transplant cures the disease. Females are obligate carriers of the mutated gene, and some show a mild Dent's disease phenotype. There may be reason for concern when considering a female obligate carrier (i.e., the mother) for kidney donation because of the risk of kidney function deterioration. Case Presentation: We describe the first successful kidney transplantation involving a patient with type 1 Dent's disease and ESRD given a kidney by an obligate carrier of the gene mutation, his mother. Conclusions: After careful assessment of the female obligate carriers, intrafamilial kidney donation in Dent's disease type 1 is feasible. No deteriorating renal function in the donor was observed.
Original languageEnglish
Pages (from-to)1306-1312
Number of pages7
Publication statusPublished - 2019


  • Dent's disease
  • Kidney transplantation
  • Living donation
  • Obligate carrier


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