Lithium carbonate in amyotrophic lateral sclerosis: lack of efficacy in a dose-finding trial

A Chiò; G Borghero; A Calvo; M Capasso; C Caponnetto; M Corbo; F Giannini; G Logroscino; J Mandrioli; N Marcello; L Mazzini; C Moglia; Monsurrò; G Mora; F Patti; V Pietrini; F Pisano; E Pupillo; Mario Sabatelli; F Salvi; V Silani; Il Simone; G Sorarù; Tola; P Volanti; E Beghi; M. Perini

doi:10.1212/WNL.0b013e3181ed9e7c

Lithium carbonate in amyotrophic lateral sclerosis: lack of efficacy in a dose-finding trial

A Chiò
, G Borghero
, A Calvo
, M Capasso
, C Caponnetto
, M Corbo
, F Giannini
, G Logroscino
, J Mandrioli
, N Marcello
, L Mazzini
, C Moglia
, Monsurrò
, G Mora
, F Patti
, V Pietrini
, F Pisano
, E Pupillo
, Mario Sabatelli
, F Salvi

V Silani, Il Simone, G Sorarù, Tola, P Volanti, E Beghi, M. Perini

University of Catania

Research output: Contribution to journal › Article

75 Citations (Scopus)

Abstract

A neuroprotective effect of lithium in amyotrophic lateral sclerosis (ALS) has been recently reported. We performed a multicenter trial with lithium carbonate to assess its tolerability, safety, and efficacy in patients with ALS, comparing 2 different target blood levels (0.4-0.8 mEq/L, therapeutic group [TG], vs 0.2-0.4 mEq/L, subtherapeutic group [STG]).

Original language	English
Pages (from-to)	619-625
Number of pages	7
Journal	Neurology
Volume	75
Issue number	7
DOIs	https://doi.org/10.1212/WNL.0b013e3181ed9e7c
Publication status	Published - 2010

Keywords

Adolescent
Adult
Aged
Amyotrophic Lateral Sclerosis
Dose-Response Relationship
Drug
Enzyme Inhibitors
Female
Follow-Up Studies
Humans
Kaplan-Meier Estimate
Lithium Carbonate
Male
Middle Aged
Retrospective Studies
Single-Blind Method
Time Factors
Treatment Outcome
Young Adult

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10.1212/WNL.0b013e3181ed9e7c

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Chiò, A., Borghero, G., Calvo, A., Capasso, M., Caponnetto, C., Corbo, M., Giannini, F., Logroscino, G., Mandrioli, J., Marcello, N., Mazzini, L., Moglia, C., Monsurrò, Mora, G., Patti, F., Pietrini, V., Pisano, F., Pupillo, E., Sabatelli, M., ... Perini, M. (2010). Lithium carbonate in amyotrophic lateral sclerosis: lack of efficacy in a dose-finding trial. Neurology, 75(7), 619-625. https://doi.org/10.1212/WNL.0b013e3181ed9e7c

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title = "Lithium carbonate in amyotrophic lateral sclerosis: lack of efficacy in a dose-finding trial",

abstract = "A neuroprotective effect of lithium in amyotrophic lateral sclerosis (ALS) has been recently reported. We performed a multicenter trial with lithium carbonate to assess its tolerability, safety, and efficacy in patients with ALS, comparing 2 different target blood levels (0.4-0.8 mEq/L, therapeutic group [TG], vs 0.2-0.4 mEq/L, subtherapeutic group [STG]).",

keywords = "Adolescent, Adult, Aged, Amyotrophic Lateral Sclerosis, Dose-Response Relationship, Drug, Enzyme Inhibitors, Female, Follow-Up Studies, Humans, Kaplan-Meier Estimate, Lithium Carbonate, Male, Middle Aged, Retrospective Studies, Single-Blind Method, Time Factors, Treatment Outcome, Young Adult, Adolescent, Adult, Aged, Amyotrophic Lateral Sclerosis, Dose-Response Relationship, Drug, Enzyme Inhibitors, Female, Follow-Up Studies, Humans, Kaplan-Meier Estimate, Lithium Carbonate, Male, Middle Aged, Retrospective Studies, Single-Blind Method, Time Factors, Treatment Outcome, Young Adult",

author = "A Chi{\`o} and G Borghero and A Calvo and M Capasso and C Caponnetto and M Corbo and F Giannini and G Logroscino and J Mandrioli and N Marcello and L Mazzini and C Moglia and Monsurr{\`o} and G Mora and F Patti and V Pietrini and F Pisano and E Pupillo and Mario Sabatelli and F Salvi and V Silani and Il Simone and G Sorar{\`u} and Tola and P Volanti and E Beghi and M. Perini",

year = "2010",

doi = "10.1212/WNL.0b013e3181ed9e7c",

language = "English",

volume = "75",

pages = "619--625",

journal = "Neurology",

issn = "0028-3878",

publisher = "Lippincott Williams and Wilkins",

number = "7",

}

Chiò, A, Borghero, G, Calvo, A, Capasso, M, Caponnetto, C, Corbo, M, Giannini, F, Logroscino, G, Mandrioli, J, Marcello, N, Mazzini, L, Moglia, C, Monsurrò, Mora, G, Patti, F, Pietrini, V, Pisano, F, Pupillo, E, Sabatelli, M, Salvi, F, Silani, V, Simone, I, Sorarù, G, Tola, Volanti, P, Beghi, E & Perini, M 2010, 'Lithium carbonate in amyotrophic lateral sclerosis: lack of efficacy in a dose-finding trial', Neurology, vol. 75, no. 7, pp. 619-625. https://doi.org/10.1212/WNL.0b013e3181ed9e7c

TY - JOUR

T1 - Lithium carbonate in amyotrophic lateral sclerosis: lack of efficacy in a dose-finding trial

AU - Chiò, A

AU - Borghero, G

AU - Calvo, A

AU - Capasso, M

AU - Caponnetto, C

AU - Corbo, M

AU - Giannini, F

AU - Logroscino, G

AU - Mandrioli, J

AU - Marcello, N

AU - Mazzini, L

AU - Moglia, C

AU - Monsurrò,

AU - Mora, G

AU - Patti, F

AU - Pietrini, V

AU - Pisano, F

AU - Pupillo, E

AU - Sabatelli, Mario

AU - Salvi, F

AU - Silani, V

AU - Simone, Il

AU - Sorarù, G

AU - Tola,

AU - Volanti, P

AU - Beghi, E

AU - Perini, M.

PY - 2010

Y1 - 2010

N2 - A neuroprotective effect of lithium in amyotrophic lateral sclerosis (ALS) has been recently reported. We performed a multicenter trial with lithium carbonate to assess its tolerability, safety, and efficacy in patients with ALS, comparing 2 different target blood levels (0.4-0.8 mEq/L, therapeutic group [TG], vs 0.2-0.4 mEq/L, subtherapeutic group [STG]).

AB - A neuroprotective effect of lithium in amyotrophic lateral sclerosis (ALS) has been recently reported. We performed a multicenter trial with lithium carbonate to assess its tolerability, safety, and efficacy in patients with ALS, comparing 2 different target blood levels (0.4-0.8 mEq/L, therapeutic group [TG], vs 0.2-0.4 mEq/L, subtherapeutic group [STG]).

KW - Adolescent

KW - Adult

KW - Aged

KW - Amyotrophic Lateral Sclerosis

KW - Dose-Response Relationship

KW - Drug

KW - Enzyme Inhibitors

KW - Female

KW - Follow-Up Studies

KW - Humans

KW - Kaplan-Meier Estimate

KW - Lithium Carbonate

KW - Male

KW - Middle Aged

KW - Retrospective Studies

KW - Single-Blind Method

KW - Time Factors

KW - Treatment Outcome

KW - Young Adult

KW - Adolescent

KW - Adult

KW - Aged

KW - Amyotrophic Lateral Sclerosis

KW - Dose-Response Relationship

KW - Drug

KW - Enzyme Inhibitors

KW - Female

KW - Follow-Up Studies

KW - Humans

KW - Kaplan-Meier Estimate

KW - Lithium Carbonate

KW - Male

KW - Middle Aged

KW - Retrospective Studies

KW - Single-Blind Method

KW - Time Factors

KW - Treatment Outcome

KW - Young Adult

UR - https://publicatt.unicatt.it/handle/10807/4501

U2 - 10.1212/WNL.0b013e3181ed9e7c

DO - 10.1212/WNL.0b013e3181ed9e7c

M3 - Article

SN - 0028-3878

VL - 75

SP - 619

EP - 625

JO - Neurology

JF - Neurology

IS - 7

ER -

Lithium carbonate in amyotrophic lateral sclerosis: lack of efficacy in a dose-finding trial

Abstract

Keywords

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