Leucocytoclastic vasculitis associated with hepatitis C virus antibodies

Giovanni Gambassi, Salvatore Caputo, Giovanni Battista Gasbarrini, Raffaele Manna, Guido Massi, L Todaro, M Latteri, Maria Grillo, A Romito

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11 Citations (Scopus)


The actiopathogenesis of leucocytoclastic vasculitis is still unknown, but recently hepatitis C virus (HCV) has been suggested as trigger of autoimmunity. We report a case of a 26-yr-old patient with purpura due to leucocytoclastic vasculitis associated with hepatitis C virus infection. Laboratory findings showed AST, ALT, gamma GT within normal limits, positive antibodies to HCV (IIF and Riba II) and polymerase chain reaction for HCV RNA. Anti-nuclear antibodies, IgG and IgM anti-cardiolipin antibodies, anti-platelet antibodies and anti-neutrophil cytoplasmic antibodies with perinuclear pattern were also present. A skin biopsy specimen of a purpuric lesion showed leucocytoclastic vasculitis with small vessel thrombosis and perivascular deposition of IgM and fibrinogen on immunofluorescence study. This case shows a role of HCV in leucocytoclastic vasculitis; it is possible that this HCV can induce autoimmunity independently of cryoglobulins and liver involvement.
Original languageEnglish
Pages (from-to)124-125
Number of pages2
JournalBritish Journal of Rheumatology
Publication statusPublished - 1997


  • Adult
  • Antibodies, Viral
  • Autoantibodies
  • Cryoglobulinemia
  • Female
  • Hepacivirus
  • Hepatitis C
  • Humans
  • Immunoglobulin G
  • Vasculitis, Leukocytoclastic, Cutaneous

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