Le sindromi autoinfiammatorie come nuovo capitolo della medicina post-genomica

Translated title of the contribution: [Autom. eng. transl.] Autoinflammatory syndromes as a new chapter in post-genomic medicine

Research output: Contribution to journalArticle

Abstract

[Autom. eng. transl.] Autoinflammatory syndromes constitute a group of inherited and acquired diseases of innate immunity that are characterized by the recurrence of febrile episodes that last from a few days to a few weeks and are accompanied by signs of multi-district inflammation of varying severity affecting the skin, of the serous, of the gastro-intestinal tract, of the osteo-articular system, etc. The vast majority of such conditions when observed in pediatrics are caused by mutations in genes involved in the control of inflammation and apoptosis mechanisms. The group includes hereditary periodic fevers, hereditary pyogenic disorders, skeletal autoinflammatory diseases, immune-mediated granulomatous diseases, idiopathic febrile syndromes, complement disorders, hemophagocytic and vasculitic syndromes. Their diagnostic identification derives from the integration of anamnestic-clinical and biohumoral data, but can be supported in some cases by genotypic studies.
Translated title of the contribution[Autom. eng. transl.] Autoinflammatory syndromes as a new chapter in post-genomic medicine
Original languageItalian
Pages (from-to)20-29
Number of pages10
JournalRivista Italiana di Pediatria Ospedaliera
Volume2011
Publication statusPublished - 2011

Keywords

  • Autoinfiammazione

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