LC-MS/MS determination of bromperidol in biological matrices: Method validation and forensic application

Fabio De Giorgio, M. Linda Felli, Nadia De Giovanni

Research output: Contribution to journalArticle

Abstract

In this paper, we describe a liquid chromatography-tandem mass spectrometry (LC-MS/MS) method used to detect the antipsychotic drug bromperidol, in biological post-mortem fluids (urine, blood and vitreous humour). The method was used to investigate an unusual case of death which occurred after bromperidol ingestion. A 44 year-old woman arrived at the emergency department in cardiac arrest. Her sister reported that the woman had taken several drops of a medicine containing bromperidol. An autopsy was performed and the biological fluid samples were submitted to a full toxicological work-up first and then to the target analysis of bromperidol. The analytical results obtained from the biological fluids collected at autopsy supported the hypothesis of death due to bromperidol intoxication.
Original languageEnglish
Pages (from-to)235-239
Number of pages5
JournalCurrent Pharmaceutical Analysis
Volume2011
Publication statusPublished - 2011

Keywords

  • LC-MS/MS
  • bromperidol

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