Late-life Enalapril administration induces nitric oxide-dependent and independent metabolic adaptations in the rat skeletal muscle

Emanuele Marzetti; Riccardo Calvani; J. DuPree; H. A. Lees; Silvia Giovannini; Seo D. -O.; T. W. Buford; K. Sweet; D. Morgan; K. Y. E. Strehler; D. Diz; S. E. Borst; N. Moningka; K. Krotova; C. S. Carter

doi:10.1007/s11357-012-9428-4

Late-life Enalapril administration induces nitric oxide-dependent and independent metabolic adaptations in the rat skeletal muscle

Emanuele Marzetti
, Riccardo Calvani
, J. DuPree
, H. A. Lees
, Silvia Giovannini
, Seo D. -O.
, T. W. Buford
, K. Sweet
, D. Morgan
, K. Y. E. Strehler
, D. Diz
, S. E. Borst
, N. Moningka
, K. Krotova
, C. S. Carter^*

^*Corresponding author

University of Florida
Wake Forest University

Research output: Contribution to journal › Article › peer-review

Abstract

Recently, we showed that administration of the angiotensin-converting enzyme inhibitor enalapril to aged rats attenuated muscle strength decline and mitigated apoptosis in the gastrocnemius muscle. The aimof the present study was to investigate possible mechanisms underlying the muscle-protective effects of enalapril. We also sought to discern the effects of enalapril mediated by nitric oxide (NO) from those independent mediated by mitigation of oxidative stress and proinflammatory signaling. © American Aging Association 2012.

Original language	English
Pages (from-to)	1061-1075
Number of pages	15
Journal	Age
Volume	35
Issue number	4
DOIs	https://doi.org/10.1007/s11357-012-9428-4
Publication status	Published - 2013

All Science Journal Classification (ASJC) codes

Ageing
Geriatrics and Gerontology

Keywords

ACE inhibitors
Aging
Glucose tolerance
Inflammation
L-NAME
MTOR
Mitochondria
Nitric oxide synthase (NOS) isoforms

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10.1007/s11357-012-9428-4

Cite this

Marzetti, E., Calvani, R., DuPree, J., Lees, H. A., Giovannini, S., -O., S. D., Buford, T. W., Sweet, K., Morgan, D., Strehler, K. Y. E., Diz, D., Borst, S. E., Moningka, N., Krotova, K., & Carter, C. S. (2013). Late-life Enalapril administration induces nitric oxide-dependent and independent metabolic adaptations in the rat skeletal muscle. Age, 35(4), 1061-1075. https://doi.org/10.1007/s11357-012-9428-4

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title = "Late-life Enalapril administration induces nitric oxide-dependent and independent metabolic adaptations in the rat skeletal muscle",

abstract = "Recently, we showed that administration of the angiotensin-converting enzyme inhibitor enalapril to aged rats attenuated muscle strength decline and mitigated apoptosis in the gastrocnemius muscle. The aimof the present study was to investigate possible mechanisms underlying the muscle-protective effects of enalapril. We also sought to discern the effects of enalapril mediated by nitric oxide (NO) from those independent mediated by mitigation of oxidative stress and proinflammatory signaling. {\textcopyright} American Aging Association 2012.",

keywords = "ACE inhibitors, Aging, Glucose tolerance, Inflammation, L-NAME, MTOR, Mitochondria, Nitric oxide synthase (NOS) isoforms, ACE inhibitors, Aging, Glucose tolerance, Inflammation, L-NAME, MTOR, Mitochondria, Nitric oxide synthase (NOS) isoforms",

author = "Emanuele Marzetti and Riccardo Calvani and J. DuPree and Lees, \{H. A.\} and Silvia Giovannini and -O., \{Seo D.\} and Buford, \{T. W.\} and K. Sweet and D. Morgan and Strehler, \{K. Y. E.\} and D. Diz and Borst, \{S. E.\} and N. Moningka and K. Krotova and Carter, \{C. S.\}",

year = "2013",

doi = "10.1007/s11357-012-9428-4",

language = "English",

volume = "35",

pages = "1061--1075",

journal = "Age",

issn = "0161-9152",

publisher = "American Aging Association (AGE)",

number = "4",

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Marzetti, E , Calvani, R, DuPree, J, Lees, HA, Giovannini, S, -O., SD, Buford, TW, Sweet, K, Morgan, D, Strehler, KYE, Diz, D, Borst, SE, Moningka, N, Krotova, K & Carter, CS 2013, 'Late-life Enalapril administration induces nitric oxide-dependent and independent metabolic adaptations in the rat skeletal muscle', Age, vol. 35, no. 4, pp. 1061-1075. https://doi.org/10.1007/s11357-012-9428-4

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AU - Marzetti, Emanuele

AU - Calvani, Riccardo

AU - DuPree, J.

AU - Lees, H. A.

AU - Giovannini, Silvia

AU - -O., Seo D.

AU - Buford, T. W.

AU - Sweet, K.

AU - Morgan, D.

AU - Strehler, K. Y. E.

AU - Diz, D.

AU - Borst, S. E.

AU - Moningka, N.

AU - Krotova, K.

AU - Carter, C. S.

PY - 2013

Y1 - 2013

N2 - Recently, we showed that administration of the angiotensin-converting enzyme inhibitor enalapril to aged rats attenuated muscle strength decline and mitigated apoptosis in the gastrocnemius muscle. The aimof the present study was to investigate possible mechanisms underlying the muscle-protective effects of enalapril. We also sought to discern the effects of enalapril mediated by nitric oxide (NO) from those independent mediated by mitigation of oxidative stress and proinflammatory signaling. © American Aging Association 2012.

AB - Recently, we showed that administration of the angiotensin-converting enzyme inhibitor enalapril to aged rats attenuated muscle strength decline and mitigated apoptosis in the gastrocnemius muscle. The aimof the present study was to investigate possible mechanisms underlying the muscle-protective effects of enalapril. We also sought to discern the effects of enalapril mediated by nitric oxide (NO) from those independent mediated by mitigation of oxidative stress and proinflammatory signaling. © American Aging Association 2012.

KW - ACE inhibitors

KW - Aging

KW - Glucose tolerance

KW - Inflammation

KW - L-NAME

KW - MTOR

KW - Mitochondria

KW - Nitric oxide synthase (NOS) isoforms

KW - ACE inhibitors

KW - Aging

KW - Glucose tolerance

KW - Inflammation

KW - L-NAME

KW - MTOR

KW - Mitochondria

KW - Nitric oxide synthase (NOS) isoforms

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VL - 35

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EP - 1075

JO - Age

JF - Age

IS - 4

ER -

Late-life Enalapril administration induces nitric oxide-dependent and independent metabolic adaptations in the rat skeletal muscle

Abstract

All Science Journal Classification (ASJC) codes

Keywords

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