Lab-on-Chip for testing myelotoxic effect of drugs and chemicals

Marco Rasponi; Andrea Gazaneo; Arianna Bonomi; Andrea Ghiglietti; Paola Occhetta; Gianfranco Beniamino Fiore; Augusto Pessina; Alberto Redaelli

doi:10.1007/s10404-015-1622-0

Lab-on-Chip for testing myelotoxic effect of drugs and chemicals

Marco Rasponi^*
, Andrea Gazaneo
, Arianna Bonomi
, Andrea Ghiglietti
, Paola Occhetta
, Gianfranco Beniamino Fiore
, Augusto Pessina
, Alberto Redaelli

^*Corresponding author

Faculty of Economics

Polytechnic University of Milan
University of Milan

Research output: Contribution to journal › Article › peer-review

10 Citations (Scopus)

Abstract

In the last 20 years, one of the main goals in the drug discovery field has been the development of reliable in vitro models. In particular, in 2006 the European Centre for the Validation of Alternative Methods has approved the colony-forming unit granulocytes–macrophages test, which is the first and currently unique test applied to evaluate the myelotoxicity of xenobiotics in vitro. The present work aimed at miniaturizing this in vitro assay by developing and validating a Lab-on-Chip platform consisting of a high number of bioreactor chambers with screening capabilities in a high-throughput regime.

Original language	English
Pages (from-to)	935-940
Number of pages	6
Journal	Microfluidics and Nanofluidics
Volume	19
Issue number	4
DOIs	https://doi.org/10.1007/s10404-015-1622-0
Publication status	Published - 2015

All Science Journal Classification (ASJC) codes

Electronic, Optical and Magnetic Materials
Condensed Matter Physics
Materials Chemistry

Keywords

CB-MNC
CFU-GM
Clonogenic test
Lab-on-Chip
Microfluidics

Access to Document

10.1007/s10404-015-1622-0

Cite this

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title = "Lab-on-Chip for testing myelotoxic effect of drugs and chemicals",

abstract = "In the last 20 years, one of the main goals in the drug discovery field has been the development of reliable in vitro models. In particular, in 2006 the European Centre for the Validation of Alternative Methods has approved the colony-forming unit granulocytes–macrophages test, which is the first and currently unique test applied to evaluate the myelotoxicity of xenobiotics in vitro. The present work aimed at miniaturizing this in vitro assay by developing and validating a Lab-on-Chip platform consisting of a high number of bioreactor chambers with screening capabilities in a high-throughput regime.",

keywords = "CB-MNC, CFU-GM, Clonogenic test, Lab-on-Chip, Microfluidics, CB-MNC, CFU-GM, Clonogenic test, Lab-on-Chip, Microfluidics",

author = "Marco Rasponi and Andrea Gazaneo and Arianna Bonomi and Andrea Ghiglietti and Paola Occhetta and Fiore, \{Gianfranco Beniamino\} and Augusto Pessina and Alberto Redaelli",

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doi = "10.1007/s10404-015-1622-0",

language = "English",

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journal = "Microfluidics and Nanofluidics",

issn = "1613-4982",

publisher = "Springer Verlag",

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}

TY - JOUR

T1 - Lab-on-Chip for testing myelotoxic effect of drugs and chemicals

AU - Rasponi, Marco

AU - Gazaneo, Andrea

AU - Bonomi, Arianna

AU - Ghiglietti, Andrea

AU - Occhetta, Paola

AU - Fiore, Gianfranco Beniamino

AU - Pessina, Augusto

AU - Redaelli, Alberto

PY - 2015

Y1 - 2015

N2 - In the last 20 years, one of the main goals in the drug discovery field has been the development of reliable in vitro models. In particular, in 2006 the European Centre for the Validation of Alternative Methods has approved the colony-forming unit granulocytes–macrophages test, which is the first and currently unique test applied to evaluate the myelotoxicity of xenobiotics in vitro. The present work aimed at miniaturizing this in vitro assay by developing and validating a Lab-on-Chip platform consisting of a high number of bioreactor chambers with screening capabilities in a high-throughput regime.

AB - In the last 20 years, one of the main goals in the drug discovery field has been the development of reliable in vitro models. In particular, in 2006 the European Centre for the Validation of Alternative Methods has approved the colony-forming unit granulocytes–macrophages test, which is the first and currently unique test applied to evaluate the myelotoxicity of xenobiotics in vitro. The present work aimed at miniaturizing this in vitro assay by developing and validating a Lab-on-Chip platform consisting of a high number of bioreactor chambers with screening capabilities in a high-throughput regime.

KW - CB-MNC

KW - CFU-GM

KW - Clonogenic test

KW - Lab-on-Chip

KW - Microfluidics

KW - CB-MNC

KW - CFU-GM

KW - Clonogenic test

KW - Lab-on-Chip

KW - Microfluidics

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U2 - 10.1007/s10404-015-1622-0

DO - 10.1007/s10404-015-1622-0

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SN - 1613-4982

VL - 19

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JO - Microfluidics and Nanofluidics

JF - Microfluidics and Nanofluidics

IS - 4

ER -

Lab-on-Chip for testing myelotoxic effect of drugs and chemicals

Abstract

All Science Journal Classification (ASJC) codes

Keywords

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