Ixekizumab exposure associated with myelitis: A case report and a literature review

Marina Romozzi; Simone Bellavia; Giacomo Caldarola; Clara De Simone; Marco Luigetti; Paolo Calabresi; Massimiliano Di Filippo; Mario Di Filippo; Carlo Masullo; Matteo Lucchini

doi:10.1016/j.jneuroim.2021.577726

Ixekizumab exposure associated with myelitis: A case report and a literature review

Marina Romozzi^*, Simone Bellavia, Giacomo Caldarola, Clara De Simone, Marco Luigetti, Paolo Calabresi, Massimiliano Di Filippo, Mario Di Filippo, Carlo Masullo, Matteo Lucchini

^*Corresponding author

University of Perugia

Research output: Contribution to journal › Article

Abstract

We describe a case of a 28-year-old man who developed a cervical myelitis while exposed to ixekizumab (IL-17 inhibitor) for psoriatic arthritis. Spinal MRI showed a T2 hyperintense lesion at the C4-C5 level while brain MRI was unspecific. Oligoclonal bands were absent and extensive screening for autoimmunity was negative. Rechallenge with ixekizumab was positive corroborating a relation between drug exposure and the neurological event. To the best of our knowledge, this is the first case of CNS inflammatory adverse event associated with ixekizumab. We also provide a review of case reports of demyelinating disorders associated with the use of biologic drugs for the treatment of psoriasis and psoriatic arthritis.

Original language	English
Pages (from-to)	1-6
Number of pages	6
Journal	Journal of Neuroimmunology
Volume	2021
DOIs	https://doi.org/10.1016/j.jneuroim.2021.577726
Publication status	Published - 2021

Keywords

Adult
Antibodies, Monoclonal, Humanized
Antirheumatic Agents
Arthritis, Psoriatic
Brain Mapping
CNS inflammation
Drug Substitution
Humans
IL-17
Immunologic Factors
Interleukin-17
Ixekizumab
Magnetic Resonance Imaging
Male
Myelitis
Paresis
Psoriatic arthritis
Spinal Cord
White Matter

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10.1016/j.jneuroim.2021.577726

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title = "Ixekizumab exposure associated with myelitis: A case report and a literature review",

abstract = "We describe a case of a 28-year-old man who developed a cervical myelitis while exposed to ixekizumab (IL-17 inhibitor) for psoriatic arthritis. Spinal MRI showed a T2 hyperintense lesion at the C4-C5 level while brain MRI was unspecific. Oligoclonal bands were absent and extensive screening for autoimmunity was negative. Rechallenge with ixekizumab was positive corroborating a relation between drug exposure and the neurological event. To the best of our knowledge, this is the first case of CNS inflammatory adverse event associated with ixekizumab. We also provide a review of case reports of demyelinating disorders associated with the use of biologic drugs for the treatment of psoriasis and psoriatic arthritis.",

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author = "Marina Romozzi and Simone Bellavia and Giacomo Caldarola and {De Simone}, Clara and Marco Luigetti and Paolo Calabresi and {Di Filippo}, Massimiliano and {Di Filippo}, Mario and Carlo Masullo and Matteo Lucchini",

year = "2021",

doi = "10.1016/j.jneuroim.2021.577726",

language = "English",

volume = "2021",

pages = "1--6",

journal = "Journal of Neuroimmunology",

issn = "0165-5728",

publisher = "Elsevier B.V.",

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TY - JOUR

T1 - Ixekizumab exposure associated with myelitis: A case report and a literature review

AU - Romozzi, Marina

AU - Bellavia, Simone

AU - Caldarola, Giacomo

AU - De Simone, Clara

AU - Luigetti, Marco

AU - Calabresi, Paolo

AU - Di Filippo, Massimiliano

AU - Di Filippo, Mario

AU - Masullo, Carlo

AU - Lucchini, Matteo

PY - 2021

Y1 - 2021

N2 - We describe a case of a 28-year-old man who developed a cervical myelitis while exposed to ixekizumab (IL-17 inhibitor) for psoriatic arthritis. Spinal MRI showed a T2 hyperintense lesion at the C4-C5 level while brain MRI was unspecific. Oligoclonal bands were absent and extensive screening for autoimmunity was negative. Rechallenge with ixekizumab was positive corroborating a relation between drug exposure and the neurological event. To the best of our knowledge, this is the first case of CNS inflammatory adverse event associated with ixekizumab. We also provide a review of case reports of demyelinating disorders associated with the use of biologic drugs for the treatment of psoriasis and psoriatic arthritis.

AB - We describe a case of a 28-year-old man who developed a cervical myelitis while exposed to ixekizumab (IL-17 inhibitor) for psoriatic arthritis. Spinal MRI showed a T2 hyperintense lesion at the C4-C5 level while brain MRI was unspecific. Oligoclonal bands were absent and extensive screening for autoimmunity was negative. Rechallenge with ixekizumab was positive corroborating a relation between drug exposure and the neurological event. To the best of our knowledge, this is the first case of CNS inflammatory adverse event associated with ixekizumab. We also provide a review of case reports of demyelinating disorders associated with the use of biologic drugs for the treatment of psoriasis and psoriatic arthritis.

KW - Adult

KW - Antibodies, Monoclonal, Humanized

KW - Antirheumatic Agents

KW - Arthritis, Psoriatic

KW - Brain Mapping

KW - CNS inflammation

KW - Drug Substitution

KW - Humans

KW - IL-17

KW - Immunologic Factors

KW - Interleukin-17

KW - Ixekizumab

KW - Magnetic Resonance Imaging

KW - Male

KW - Myelitis

KW - Paresis

KW - Psoriatic arthritis

KW - Spinal Cord

KW - White Matter

KW - Adult

KW - Antibodies, Monoclonal, Humanized

KW - Antirheumatic Agents

KW - Arthritis, Psoriatic

KW - Brain Mapping

KW - CNS inflammation

KW - Drug Substitution

KW - Humans

KW - IL-17

KW - Immunologic Factors

KW - Interleukin-17

KW - Ixekizumab

KW - Magnetic Resonance Imaging

KW - Male

KW - Myelitis

KW - Paresis

KW - Psoriatic arthritis

KW - Spinal Cord

KW - White Matter

UR - http://hdl.handle.net/10807/202955

U2 - 10.1016/j.jneuroim.2021.577726

DO - 10.1016/j.jneuroim.2021.577726

M3 - Article

SN - 0165-5728

VL - 2021

SP - 1

EP - 6

JO - Journal of Neuroimmunology

JF - Journal of Neuroimmunology

ER -

Ixekizumab exposure associated with myelitis: A case report and a literature review

Abstract

Keywords

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