Isolated light chain deposition disease neuropathy in a patient with multiple myeloma

In our patient, clinical history, neurological examination\r\nand NCS revealed a progressive axonal sensory-motor polyneuropathy.\r\nAlthough the presence of a polyneuropathy in\r\npatients with MM is quite common, the rapid progression\r\nof her clinical condition suggested a direct association with\r\nthe underlying hematologic disease [3]. Ruled out other possible\r\ncauses of neuropathy, we performed nerve biopsy,\r\ndetecting abundant light chain deposition and thus confirming\r\nan aggressive hematologic disease, although other organs\r\n(including kidney and heart) were not involved. Based on\r\nthese considerations, our patient was treated with chemotherapy,\r\nresulting in clinical stabilization.\r\nThis report confirms that LCDD, although rare, could be\r\none of the several mechanisms of nerve damage in hematologic\r\ndiseases and could occur even without signs of other\r\norgan involvement. Since its recognition has important\r\ntherapeutic implications, nerve biopsy is an irreplaceable\r\ndiagnostic tool in patients with progressive neuropathy during\r\nhematologic disease.