Is the pCO(2) gap obtained from the superior vena cava in agreement with that from the pulmonary artery?

Franco Cavaliere, Michele Corrado, Sergio Guarneri, Andrea Scapigliati, Maria Enrica Antoniucci, Gabriella Arlotta, Stefano De Paulis

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

BACKGROUND: The partial pressure of carbon dioxide (pCO(2)) gap is the difference between pCO(2) values in the arterial and mixed venous blood; values higher than six mmHg may be predictive of tissue hypoperfusion. It is still doubtful if central venous blood can be used to assess the gap. This study was aimed to compare the values obtained with blood collected from the superior vena cava and the pulmonary artery.METHODS: Data were obtained from a previous study. In 30 patients who underwent on-pump myocardial revascularization, blood samples from a radial artery, the pulmonary artery, and the superior vena cava were collected eight times in the perioperative period. Two-hundred determinations were utilized to calculate the pCO(2) gap from central and mixed venous pCO(2).RESULTS: The pCO(2) gap was 8.7 +/- 2.6 mmHg in the superior vena cava, and 6.0 +/- 2.7 in the pulmonary artery. The difference between the two values fell within a wide interval between -4.1 mmHg and +9.5 mmHg in 95% of cases. pCO(2) values were significantly higher in the superior vena cava than in the pulmonary artery (mean difference 2.7 +/- 2.4 mmHg; P<0.0001), causing a systematic bias between the two estimates; such bias increased during spontaneous breathing (P=0.0249).CONCLUSIONS: pCO(2) values are higher in the superior vena cava than in the pulmonary artery. As a consequence, the pCO(2) gap calculated with the blood taken from the superior vena cava is overestimated, probably because it reflects the pCO(2) arteriovenous difference of the upper part of the body, in particular of the brain.
Original languageEnglish
Pages (from-to)1308-1314
Number of pages7
JournalMINERVA ANESTESIOLOGICA
Volume85
DOIs
Publication statusPublished - 2019

Keywords

  • Aged
  • Blood Gas Analysis
  • Blood gas monitoring
  • Carbon Dioxide
  • Carbon dioxide
  • Cardiac output
  • Female
  • Hemodynamics
  • Humans
  • Male
  • Middle Aged
  • Pulmonary Artery
  • Retrospective Studies
  • Vena Cava, Superior

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