Is immune modulation the mechanism underlying the beneficial effects of amniotic cells and their derivatives in regenerative medicine?

Antonietta R. Silini, Marta Magatti, Anna Cargnoni, Ornella Parolini*

*Corresponding author

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

Regenerative medicine aims to repair and regenerate damaged cells, tissues, and organs in order to restore function. Regeneration can be obtained either by cell replacement or by stimulating the body’s own repair mechanisms. Importantly, a favorable environment is required before any regenerative signal can stimulate resident stem/stromal cells, and regeneration is possible only after the resolution of injury-induced inflammation. An exacerbated immune response is often present in cases of degenerative, inflammatory-based diseases. Here we discuss how amniotic membrane cells, and their derivatives, can contribute to the resolution of many diseases with altered immune response by acting on different inflammatory mediators.
Original languageEnglish
Pages (from-to)531-539
Number of pages9
JournalCell Transplantation
DOIs
Publication statusPublished - 2016

Keywords

  • Human placenta, amniotic membrane, amniotic mesenchymal stromal/stem cells, amniotic epithelial cells, immune-modulation, paracrine mechanism

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