Is Health-Related Quality of Life after Radical Cystectomy Using Validated Questionnaires Really Better in Patients with Ileal Orthotopic Neobladder Compared to Ileal Conduit: A Meta-Analysis of Retrospective Comparative Studies

Pierfrancesco Bassi, Marco Racioppi, Maria A. Cerruto, Carolina D'Elia, Salvatore Siracusano, Antonio B. Porcaro, Giovanni Cacciamani, Davide De Marchi, Mauro Niero, Cristina Lonardi, Massimo Iafrate, Emanuele Belgrano, Ciro Imbimbo, Renato Talamini, Stefano Ciciliato, Laura Toffoli, Michele Rizzo, Francesco Visalli, Paolo Verze, Walter Artibani

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Introduction From the most recent systematic revision of the literature, an orthotopic neobladder would seem to show marginally better health related quality of life (HR-QoL) scores compared with an ileal conduit. The aim of this study was to review all relevant published studies about the comparison between ileal orthotopic neobladder (IONB) and ileal conduit using validated HR-QoL questionnaires. Materials and Methods Studies were identified by searching multiple literature databases. Data were synthesized using meta-analytic methods conformed to the PRISMA statement. Results The literature search identified 10 papers; pooled effect sizes of combined quality of life outcomes for ileal conduit versus IONB showed a significantly better HR-QoL in patients with IONB (Hedges' g = 0.278; p = 0.000);. The present study has an important limitation due to the type of the analyzed comparative studies, all retrospective and not randomized. Conclusion This meta-analysis of not-randomized, retrospective comparative studies on the impact of ileal conduit versus IONB on HR-QoL showed a significant advantage of IONB subgroups.
Original languageEnglish
Pages (from-to)57-68
Number of pages12
JournalCurrent Urology Reports
DOIs
Publication statusPublished - 2017

Keywords

  • Radical cystectomy
  • Health related quality of life
  • Neobladder
  • Ileal conduit
  • Urinary diversion

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