Involvement of Fas/FasL system in the pathogenesis of autoimmune diseases and Wilson's disease

Giorgio Stassi; Valentina Di Felice; Matilde Todaro; Francesco Cappello; Giovanni Zummo; Felicia Farina; Massimo Trucco; Ruggero De Maria Marchiano

Involvement of Fas/FasL system in the pathogenesis of autoimmune diseases and Wilson's disease

Giorgio Stassi, Valentina Di Felice, Matilde Todaro, Francesco Cappello, Giovanni Zummo, Felicia Farina, Massimo Trucco, Ruggero De Maria Marchiano

University of Palermo

Research output: Contribution to journal › Article

10 Citations (Scopus)

Abstract

The interaction of Fas with FasL has been demonstrated to be implicated in the pathogenesis of several autoimmune and liver diseases. Recently, attention has been focused on the hypothesis that thyrocytes and Î² cells undergo massive Fas/FasL-mediated apoptosis during autoimmune response. Similarly, hepatocyte cell death occurring following copper accumulation points towards the same mechanism.

Original language	English
Pages (from-to)	129-133
Number of pages	5
Journal	Archivum Immunologiae et Therapiae Experimentalis
Volume	47
Publication status	Published - 1999

Keywords

Apoptosis
Autoimmune diseases
Fas
Hashimoto's thyroiditis
Immunology
Insulin-dependent diabetes mellitus
Wilson's disease

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This output contributes to the following UN Sustainable Development Goals (SDGs)

Cite this

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title = "Involvement of Fas/FasL system in the pathogenesis of autoimmune diseases and Wilson's disease",

abstract = "The interaction of Fas with FasL has been demonstrated to be implicated in the pathogenesis of several autoimmune and liver diseases. Recently, attention has been focused on the hypothesis that thyrocytes and {\^I}² cells undergo massive Fas/FasL-mediated apoptosis during autoimmune response. Similarly, hepatocyte cell death occurring following copper accumulation points towards the same mechanism.",

keywords = "Apoptosis, Autoimmune diseases, Fas, Hashimoto's thyroiditis, Immunology, Insulin-dependent diabetes mellitus, Wilson's disease, Apoptosis, Autoimmune diseases, Fas, Hashimoto's thyroiditis, Immunology, Insulin-dependent diabetes mellitus, Wilson's disease",

author = "Giorgio Stassi and Felice, {Valentina Di} and Matilde Todaro and Francesco Cappello and Giovanni Zummo and Felicia Farina and Massimo Trucco and {De Maria Marchiano}, Ruggero",

year = "1999",

language = "English",

volume = "47",

pages = "129--133",

journal = "Archivum Immunologiae et Therapiae Experimentalis",

issn = "0004-069X",

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TY - JOUR

T1 - Involvement of Fas/FasL system in the pathogenesis of autoimmune diseases and Wilson's disease

AU - Stassi, Giorgio

AU - Felice, Valentina Di

AU - Todaro, Matilde

AU - Cappello, Francesco

AU - Zummo, Giovanni

AU - Farina, Felicia

AU - Trucco, Massimo

AU - De Maria Marchiano, Ruggero

PY - 1999

Y1 - 1999

N2 - The interaction of Fas with FasL has been demonstrated to be implicated in the pathogenesis of several autoimmune and liver diseases. Recently, attention has been focused on the hypothesis that thyrocytes and Î² cells undergo massive Fas/FasL-mediated apoptosis during autoimmune response. Similarly, hepatocyte cell death occurring following copper accumulation points towards the same mechanism.

AB - The interaction of Fas with FasL has been demonstrated to be implicated in the pathogenesis of several autoimmune and liver diseases. Recently, attention has been focused on the hypothesis that thyrocytes and Î² cells undergo massive Fas/FasL-mediated apoptosis during autoimmune response. Similarly, hepatocyte cell death occurring following copper accumulation points towards the same mechanism.

KW - Apoptosis

KW - Autoimmune diseases

KW - Fas

KW - Hashimoto's thyroiditis

KW - Immunology

KW - Insulin-dependent diabetes mellitus

KW - Wilson's disease

KW - Apoptosis

KW - Autoimmune diseases

KW - Fas

KW - Hashimoto's thyroiditis

KW - Immunology

KW - Insulin-dependent diabetes mellitus

KW - Wilson's disease

UR - http://hdl.handle.net/10807/114426

M3 - Article

SN - 0004-069X

VL - 47

SP - 129

EP - 133

JO - Archivum Immunologiae et Therapiae Experimentalis

JF - Archivum Immunologiae et Therapiae Experimentalis

ER -

Involvement of Fas/FasL system in the pathogenesis of autoimmune diseases and Wilson's disease

Abstract

Keywords

UN SDGs

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