Investigating the role of DNA damage in tobacco smoking-induced spine degeneration

Luigi Aurelio Nasto, Kevin Ngo, Adriana S. Leme, Andria R. Robinson, Qing Dong, Peter Roughley, Arvydas Usas, Gwendolyn A. Sowa, Enrico Pola, James Kang, Laura J. Niedernhofer, Steven Shapiro, Nam V. Vo

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

Tobacco smoking is a key risk factor for spine degeneration. However, the underlying mechanism by which smoking induces degeneration is not known. Recent studies implicate DNA damage as a cause of spine and intervertebral disc degeneration. Because tobacco smoke contains many genotoxins, we hypothesized that tobacco smoking promotes spine degeneration by inducing cellular DNA damage.
Original languageEnglish
Pages (from-to)1529-1532
Number of pages4
JournalTHE SPINE JOURNAL
DOIs
Publication statusPublished - 2013

Keywords

  • Aggrecan
  • DNA damage repair
  • Intervertebral disc degeneration
  • Matrix metalloproteinases
  • Matrix proteoglycans
  • Tobacco smoking

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