Invasive growth: A two-way street for semaphorin signalling

Polo M. Comoglio; Luca Tamagnone; Silvia Giordano

doi:10.1038/ncb1204-1155

Invasive growth: A two-way street for semaphorin signalling

Polo M. Comoglio
, Luca Tamagnone
, Silvia Giordano

University of Turin

Research output: Contribution to journal › Article

18 Citations (Scopus)

Abstract

Growing evidence suggests that semaphorins - known to provide directional cues during axon guidance - also provide regulatory signals for cell migration during tissue morphogenesis. During heart development, it is crucial that semaphorins can signal bidirectionally, functioning as both a ligand and a receptor. Through these distinct signalling pathways, semaphorins can provide both 'stop' and 'go' signals for cell motility and invasive growth.

Original language	English
Pages (from-to)	1155-1157
Number of pages	3
Journal	Nature Cell Biology
Volume	6
DOIs	https://doi.org/10.1038/ncb1204-1155
Publication status	Published - 2004

Keywords

SEMAPHORINS

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10.1038/ncb1204-1155

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title = "Invasive growth: A two-way street for semaphorin signalling",

abstract = "Growing evidence suggests that semaphorins - known to provide directional cues during axon guidance - also provide regulatory signals for cell migration during tissue morphogenesis. During heart development, it is crucial that semaphorins can signal bidirectionally, functioning as both a ligand and a receptor. Through these distinct signalling pathways, semaphorins can provide both 'stop' and 'go' signals for cell motility and invasive growth.",

keywords = "SEMAPHORINS, SEMAPHORINS",

author = "Comoglio, \{Polo M.\} and Luca Tamagnone and Silvia Giordano",

year = "2004",

doi = "10.1038/ncb1204-1155",

language = "English",

volume = "6",

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journal = "Nature Cell Biology",

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T1 - Invasive growth: A two-way street for semaphorin signalling

AU - Comoglio, Polo M.

AU - Tamagnone, Luca

AU - Giordano, Silvia

PY - 2004

Y1 - 2004

N2 - Growing evidence suggests that semaphorins - known to provide directional cues during axon guidance - also provide regulatory signals for cell migration during tissue morphogenesis. During heart development, it is crucial that semaphorins can signal bidirectionally, functioning as both a ligand and a receptor. Through these distinct signalling pathways, semaphorins can provide both 'stop' and 'go' signals for cell motility and invasive growth.

AB - Growing evidence suggests that semaphorins - known to provide directional cues during axon guidance - also provide regulatory signals for cell migration during tissue morphogenesis. During heart development, it is crucial that semaphorins can signal bidirectionally, functioning as both a ligand and a receptor. Through these distinct signalling pathways, semaphorins can provide both 'stop' and 'go' signals for cell motility and invasive growth.

KW - SEMAPHORINS

UR - http://hdl.handle.net/10807/141388

U2 - 10.1038/ncb1204-1155

DO - 10.1038/ncb1204-1155

M3 - Article

SN - 1465-7392

VL - 6

SP - 1155

EP - 1157

JO - Nature Cell Biology

JF - Nature Cell Biology

ER -

Invasive growth: A two-way street for semaphorin signalling

Abstract

Keywords

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