Invasive growth: A two-way street for semaphorin signalling

Polo M. Comoglio, Luca Tamagnone, Silvia Giordano

Research output: Contribution to journalArticle

18 Citations (Scopus)


Growing evidence suggests that semaphorins - known to provide directional cues during axon guidance - also provide regulatory signals for cell migration during tissue morphogenesis. During heart development, it is crucial that semaphorins can signal bidirectionally, functioning as both a ligand and a receptor. Through these distinct signalling pathways, semaphorins can provide both 'stop' and 'go' signals for cell motility and invasive growth.
Original languageEnglish
Pages (from-to)1155-1157
Number of pages3
JournalNature Cell Biology
Publication statusPublished - 2004




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