Intra- and inter-nerve cross sectional area variability: new ultrasound measures

Luca Padua, Costanza Pazzaglia, Giuseppe Granata, C Martinoli, M Lucchetta, C Erra, C. Briani

Research output: Contribution to journalArticle

83 Citations (Scopus)


INTRODUCTION: Nerve involvement in immune-related neuropathies is non-homogeneous, and therefore characterization of ultrasound (US) abnormalities is difficult. We developed two measures to quantify US abnormalities in immune-related neuropathies. METHODS: Intranerve cross-sectional area (CSA) variability for each nerve was calculated as: maximal CSA/minimal CSA. Internerve CSA variability for each patient was calculated as: maximal intranerve CSA variability/minimal intranerve CSA variability. Six patients underwent US evaluation of the median, ulnar, and fibular nerves, and the abnormalities were scored with our newly developed measures. RESULTS: The new measures were applicable to all nerves and patients. The highest degree of intra- and internerve CSA variability was observed in multifocal motor neuropathy, consistent with the asymmetric characteristics of this neuropathy. CONCLUSIONS: The application of intra- and internerve CSA variability measures allows us to quantify the heterogeneity of nerves and nerve segments and identify different US patterns in diverse immune-related neuropathies.
Original languageEnglish
Pages (from-to)730-733
Number of pages4
Publication statusPublished - 2012


  • cross-sectional area
  • diagnosis
  • immune-related neuropathies
  • nerve volume
  • outcome measures
  • ultrasound measures
  • variability


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