International consensus statement on the diagnosis and management of phaeochromocytoma and paraganglioma in children and adolescents

Ruth T Casey; Emile Hendriks; Cheri Deal; Steven G Waguespack; Verena Wiegering; Antje Redlich; Scott Akker; Rathi Prasad; Martin Fassnacht; Roderick Clifton-Bligh; Laurence Amar; Stefan Bornstein; Letizia Canu; Evangelia Charmandari; Alexandra Chrisoulidou; Maria Currás Freixes; Ronald de Krijger; Luisa de Sanctis; Antonio Fojo; Amol J Ghia; Angela Huebner; Vasilis Kosmoliaptsis; Michaela Kuhlen; Marco Raffaelli; Charlotte Lussey-Lepoutre; Stephen D Marks; Naris Nilubol; Mirko Parasiliti-Caprino; Henri H J L M Timmers; Anna Lena Zietlow; Mercedes Robledo; Anne-Paule Gimenez-Roqueplo; Ashley B Grossman; David Taïeb; Eamonn R Maher; Jacques W M Lenders; Graeme Eisenhofer; Camilo Jimenez; Karel Pacak; Christina Pamporaki

doi:10.1038/s41574-024-01024-5

International consensus statement on the diagnosis and management of phaeochromocytoma and paraganglioma in children and adolescents

Ruth T Casey^*
, Emile Hendriks
, Cheri Deal
, Steven G Waguespack
, Verena Wiegering
, Antje Redlich
, Scott Akker
, Rathi Prasad
, Martin Fassnacht
, Roderick Clifton-Bligh
, Laurence Amar
, Stefan Bornstein
, Letizia Canu
, Evangelia Charmandari
, Alexandra Chrisoulidou
, Maria Currás Freixes
, Ronald de Krijger
, Luisa de Sanctis
, Antonio Fojo
, Amol J Ghia

Angela Huebner, Vasilis Kosmoliaptsis, Michaela Kuhlen, Marco Raffaelli, Charlotte Lussey-Lepoutre, Stephen D Marks, Naris Nilubol, Mirko Parasiliti-Caprino, Henri H J L M Timmers, Anna Lena Zietlow, Mercedes Robledo, Anne-Paule Gimenez-Roqueplo, Ashley B Grossman, David Taïeb, Eamonn R Maher, Jacques W M Lenders, Graeme Eisenhofer, Camilo Jimenez, Karel Pacak, Christina Pamporaki^*

^*Corresponding author

Cambridge University Hospitals NHS Foundation Trust
University of Würzburg
Otto von Guericke University Magdeburg
St Bartholomew's Hospital
Queen Mary University of London
Royal North Shore Hospital
Assistance publique – Hôpitaux de Paris
Université de Paris
Technische Universität Dresden (TU Dresden)
Azienda Ospedaliera Careggi
University of Florence
National and Kapodistrian University of Athens
Centro de Investigación Biomédica en Red
Princess Máxima Center for Pediatric Oncology
Utrecht University
University of Turin
Columbia University
University of Cambridge
Augsburg University
Sorbonne Université
National Institutes of Health
Technische Universität Dresden
Hopital La Timone
University of Texas MD Anderson Cancer Center

Research output: Contribution to journal › Meeting Abstract

Abstract

Phaeochromocytomas and paragangliomas (PPGL) are rare neuroendocrine tumours that arise not only in adulthood but also in childhood and adolescence. Up to 70–80% of childhood PPGL are hereditary, accounting for a higher incidence of metastatic and/or multifocal PPGL in paediatric patients than in adult patients. Key differences in the tumour biology and management, together with rare disease incidence and therapeutic challenges in paediatric compared with adult patients, mandate close expert cross-disciplinary teamwork. Teams should ideally include adult and paediatric endocrinologists, oncologists, cardiologists, surgeons, geneticists, pathologists, radiologists, clinical psychologists and nuclear medicine physicians. Provision of an international Consensus Statement should improve care and outcomes for children and adolescents with these tumours.

Original language	English
Pages (from-to)	729-748
Number of pages	20
Journal	Nature Reviews Endocrinology
Volume	20
Issue number	12
DOIs	https://doi.org/10.1038/s41574-024-01024-5
Publication status	Published - 2024

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

All Science Journal Classification (ASJC) codes

Endocrinology, Diabetes and Metabolism
Endocrinology

Keywords

phaeochromocytoma
paraganglioma in children

Access to Document

10.1038/s41574-024-01024-5

Cite this

Casey, R. T., Hendriks, E., Deal, C., Waguespack, S. G., Wiegering, V., Redlich, A., Akker, S., Prasad, R., Fassnacht, M., Clifton-Bligh, R., Amar, L., Bornstein, S., Canu, L., Charmandari, E., Chrisoulidou, A., Freixes, M. C., de Krijger, R., de Sanctis, L., Fojo, A., ... Pamporaki, C. (2024). International consensus statement on the diagnosis and management of phaeochromocytoma and paraganglioma in children and adolescents. Nature Reviews Endocrinology, 20(12), 729-748. https://doi.org/10.1038/s41574-024-01024-5

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title = "International consensus statement on the diagnosis and management of phaeochromocytoma and paraganglioma in children and adolescents",

abstract = "Phaeochromocytomas and paragangliomas (PPGL) are rare neuroendocrine tumours that arise not only in adulthood but also in childhood and adolescence. Up to 70–80\% of childhood PPGL are hereditary, accounting for a higher incidence of metastatic and/or multifocal PPGL in paediatric patients than in adult patients. Key differences in the tumour biology and management, together with rare disease incidence and therapeutic challenges in paediatric compared with adult patients, mandate close expert cross-disciplinary teamwork. Teams should ideally include adult and paediatric endocrinologists, oncologists, cardiologists, surgeons, geneticists, pathologists, radiologists, clinical psychologists and nuclear medicine physicians. Provision of an international Consensus Statement should improve care and outcomes for children and adolescents with these tumours.",

keywords = "phaeochromocytoma, paraganglioma in children, phaeochromocytoma, paraganglioma in children",

author = "Casey, \{Ruth T\} and Emile Hendriks and Cheri Deal and Waguespack, \{Steven G\} and Verena Wiegering and Antje Redlich and Scott Akker and Rathi Prasad and Martin Fassnacht and Roderick Clifton-Bligh and Laurence Amar and Stefan Bornstein and Letizia Canu and Evangelia Charmandari and Alexandra Chrisoulidou and Freixes, \{Maria Curr{\'a}s\} and \{de Krijger\}, Ronald and \{de Sanctis\}, Luisa and Antonio Fojo and Ghia, \{Amol J\} and Angela Huebner and Vasilis Kosmoliaptsis and Michaela Kuhlen and Marco Raffaelli and Charlotte Lussey-Lepoutre and Marks, \{Stephen D\} and Naris Nilubol and Mirko Parasiliti-Caprino and Timmers, \{Henri H J L M\} and Zietlow, \{Anna Lena\} and Mercedes Robledo and Anne-Paule Gimenez-Roqueplo and Grossman, \{Ashley B\} and David Ta{\"i}eb and Maher, \{Eamonn R\} and Lenders, \{Jacques W M\} and Graeme Eisenhofer and Camilo Jimenez and Karel Pacak and Christina Pamporaki",

year = "2024",

doi = "10.1038/s41574-024-01024-5",

language = "English",

volume = "20",

pages = "729--748",

journal = "Nature Reviews Endocrinology",

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Casey, RT, Hendriks, E, Deal, C, Waguespack, SG, Wiegering, V, Redlich, A, Akker, S, Prasad, R, Fassnacht, M, Clifton-Bligh, R, Amar, L, Bornstein, S, Canu, L, Charmandari, E, Chrisoulidou, A, Freixes, MC, de Krijger, R, de Sanctis, L, Fojo, A, Ghia, AJ, Huebner, A, Kosmoliaptsis, V, Kuhlen, M, Raffaelli, M, Lussey-Lepoutre, C, Marks, SD, Nilubol, N, Parasiliti-Caprino, M, Timmers, HHJLM, Zietlow, AL, Robledo, M, Gimenez-Roqueplo, A-P, Grossman, AB, Taïeb, D, Maher, ER, Lenders, JWM, Eisenhofer, G, Jimenez, C, Pacak, K & Pamporaki, C 2024, 'International consensus statement on the diagnosis and management of phaeochromocytoma and paraganglioma in children and adolescents', Nature Reviews Endocrinology, vol. 20, no. 12, pp. 729-748. https://doi.org/10.1038/s41574-024-01024-5

TY - JOUR

T1 - International consensus statement on the diagnosis and management of phaeochromocytoma and paraganglioma in children and adolescents

AU - Casey, Ruth T

AU - Hendriks, Emile

AU - Deal, Cheri

AU - Waguespack, Steven G

AU - Wiegering, Verena

AU - Redlich, Antje

AU - Akker, Scott

AU - Prasad, Rathi

AU - Fassnacht, Martin

AU - Clifton-Bligh, Roderick

AU - Amar, Laurence

AU - Bornstein, Stefan

AU - Canu, Letizia

AU - Charmandari, Evangelia

AU - Chrisoulidou, Alexandra

AU - Freixes, Maria Currás

AU - de Krijger, Ronald

AU - de Sanctis, Luisa

AU - Fojo, Antonio

AU - Ghia, Amol J

AU - Huebner, Angela

AU - Kosmoliaptsis, Vasilis

AU - Kuhlen, Michaela

AU - Raffaelli, Marco

AU - Lussey-Lepoutre, Charlotte

AU - Marks, Stephen D

AU - Nilubol, Naris

AU - Parasiliti-Caprino, Mirko

AU - Timmers, Henri H J L M

AU - Zietlow, Anna Lena

AU - Robledo, Mercedes

AU - Gimenez-Roqueplo, Anne-Paule

AU - Grossman, Ashley B

AU - Taïeb, David

AU - Maher, Eamonn R

AU - Lenders, Jacques W M

AU - Eisenhofer, Graeme

AU - Jimenez, Camilo

AU - Pacak, Karel

AU - Pamporaki, Christina

PY - 2024

Y1 - 2024

N2 - Phaeochromocytomas and paragangliomas (PPGL) are rare neuroendocrine tumours that arise not only in adulthood but also in childhood and adolescence. Up to 70–80% of childhood PPGL are hereditary, accounting for a higher incidence of metastatic and/or multifocal PPGL in paediatric patients than in adult patients. Key differences in the tumour biology and management, together with rare disease incidence and therapeutic challenges in paediatric compared with adult patients, mandate close expert cross-disciplinary teamwork. Teams should ideally include adult and paediatric endocrinologists, oncologists, cardiologists, surgeons, geneticists, pathologists, radiologists, clinical psychologists and nuclear medicine physicians. Provision of an international Consensus Statement should improve care and outcomes for children and adolescents with these tumours.

AB - Phaeochromocytomas and paragangliomas (PPGL) are rare neuroendocrine tumours that arise not only in adulthood but also in childhood and adolescence. Up to 70–80% of childhood PPGL are hereditary, accounting for a higher incidence of metastatic and/or multifocal PPGL in paediatric patients than in adult patients. Key differences in the tumour biology and management, together with rare disease incidence and therapeutic challenges in paediatric compared with adult patients, mandate close expert cross-disciplinary teamwork. Teams should ideally include adult and paediatric endocrinologists, oncologists, cardiologists, surgeons, geneticists, pathologists, radiologists, clinical psychologists and nuclear medicine physicians. Provision of an international Consensus Statement should improve care and outcomes for children and adolescents with these tumours.

KW - phaeochromocytoma

KW - paraganglioma in children

KW - phaeochromocytoma

KW - paraganglioma in children

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U2 - 10.1038/s41574-024-01024-5

DO - 10.1038/s41574-024-01024-5

M3 - Meeting Abstract

SN - 1759-5029

VL - 20

SP - 729

EP - 748

JO - Nature Reviews Endocrinology

JF - Nature Reviews Endocrinology

IS - 12

ER -

International consensus statement on the diagnosis and management of phaeochromocytoma and paraganglioma in children and adolescents

Abstract

UN SDGs

All Science Journal Classification (ASJC) codes

Keywords

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