Interleukin-17 in atherosclerosis and cardiovascular disease: the good, the bad, and the unknown

Giovanna Liuzzo; Francesco Trotta; Daniela Pedicino

doi:10.1093/eurheartj/ehs399

Interleukin-17 in atherosclerosis and cardiovascular disease: the good, the bad, and the unknown

Giovanna Liuzzo, Francesco Trotta, Daniela Pedicino

Research output: Contribution to journal › Article › peer-review

53 Citations (Scopus)

Abstract

Over the past few years our understanding of the importance of adaptive immunity in acute coronary syndromes (ACS) has considerably increased. Profound abnormalities have been observed in specific subsets of CD4+T cells, including type 1 helper T (Th1) cells,CD4+CD28nullT cells, and naturally occurring regulatory T cells (Treg cells). Recently a new lineage of CD4+T cells, type 17 helper T (Th17) cells producing the signature cytokines interleukin (IL)-17, IL-21, and IL-22, has been identified. This has fundamentally changed the Th1/Th2 dichotomy paradigm.

Original language	English
Pages (from-to)	556-559
Number of pages	4
Journal	European Heart Journal
Volume	34
DOIs	https://doi.org/10.1093/eurheartj/ehs399
Publication status	Published - 2013

Keywords

Acute Coronary Syndromes
Atherosclerosis
Immune system
Interleukin-17

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1093/eurheartj/ehs399

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title = "Interleukin-17 in atherosclerosis and cardiovascular disease: the good, the bad, and the unknown",

abstract = "Over the past few years our understanding of the importance of adaptive immunity in acute coronary syndromes (ACS) has considerably increased. Profound abnormalities have been observed in specific subsets of CD4+T cells, including type 1 helper T (Th1) cells,CD4+CD28nullT cells, and naturally occurring regulatory T cells (Treg cells). Recently a new lineage of CD4+T cells, type 17 helper T (Th17) cells producing the signature cytokines interleukin (IL)-17, IL-21, and IL-22, has been identified. This has fundamentally changed the Th1/Th2 dichotomy paradigm.",

keywords = "Acute Coronary Syndromes, Atherosclerosis, Immune system, Interleukin-17, Acute Coronary Syndromes, Atherosclerosis, Immune system, Interleukin-17",

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AU - Liuzzo, Giovanna

AU - Trotta, Francesco

AU - Pedicino, Daniela

PY - 2013

Y1 - 2013

N2 - Over the past few years our understanding of the importance of adaptive immunity in acute coronary syndromes (ACS) has considerably increased. Profound abnormalities have been observed in specific subsets of CD4+T cells, including type 1 helper T (Th1) cells,CD4+CD28nullT cells, and naturally occurring regulatory T cells (Treg cells). Recently a new lineage of CD4+T cells, type 17 helper T (Th17) cells producing the signature cytokines interleukin (IL)-17, IL-21, and IL-22, has been identified. This has fundamentally changed the Th1/Th2 dichotomy paradigm.

AB - Over the past few years our understanding of the importance of adaptive immunity in acute coronary syndromes (ACS) has considerably increased. Profound abnormalities have been observed in specific subsets of CD4+T cells, including type 1 helper T (Th1) cells,CD4+CD28nullT cells, and naturally occurring regulatory T cells (Treg cells). Recently a new lineage of CD4+T cells, type 17 helper T (Th17) cells producing the signature cytokines interleukin (IL)-17, IL-21, and IL-22, has been identified. This has fundamentally changed the Th1/Th2 dichotomy paradigm.

KW - Acute Coronary Syndromes

KW - Atherosclerosis

KW - Immune system

KW - Interleukin-17

KW - Acute Coronary Syndromes

KW - Atherosclerosis

KW - Immune system

KW - Interleukin-17

UR - http://hdl.handle.net/10807/43141

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DO - 10.1093/eurheartj/ehs399

M3 - Article

SN - 0195-668X

VL - 34

SP - 556

EP - 559

JO - European Heart Journal

JF - European Heart Journal

ER -

Interleukin-17 in atherosclerosis and cardiovascular disease: the good, the bad, and the unknown

Abstract

Keywords

UN SDGs

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