Interferenti endocrini e tiroide: è tempo di una prevenzione integrata per ridurre i fattori di rischio ambientali

Translated title of the contribution: [Autom. eng. transl.] Endocrine disruptors and thyroid: it's time for integrated prevention to reduce environmental risk factors

Salvatore Maria Corsello, Rosa Maria Paragliola, Gualtiero Ricciardi, Umberto Moscato, Daniele Ignazio La Milia, Andrea Poscia, M Pianalto

Research output: Chapter in Book/Report/Conference proceedingConference contribution


[Autom. eng. transl.] Endocrine disruptors (IE) or Endocrine Disruptors are ubiquitous compounds, natural or artificial, that can alter physiological hormonal homeostasis and are a controversial environmental issue for public health. The present study shows the conclusions derived from a systematic review of the literature on the relationship between IE and thyroid dysfunction / disease. The research was based on a comprehensive review of publications on PubMed and part of those of Embase and Cochrane Library, including all publications in English, Italian and Spanish on the subject; They were excluded non-human studies. Two reviewers conducted the research independently, in February 2012 and supplemented in February 2013; at the end of the review process, 98 primary studies and 61 reviews were selected (out of 1581 articles and 239 revisions initially found). Of the 61 selected reviews were summarized in this paper the 5 most recent (published in 2008-2010) who had already included and reviewed 78 of the 98 articles obtained through systematic research. They are, therefore, analyzed the 20 remaining items to update what already exists in the literature. Our study shows a relationship between IE exposure and the alteration of FT3, FT4 and TSH, especially for polychlorobiphenyls, polybrominated diphenylethers, perchlorate and dioxins or dioxin-like compounds. However, no study shows a significant relationship with any pathological and clinical expression of thyroid disease, especially because of the different environmental and genetic factors and confounding factors present in observational studies. Particular risk conditions are represented by the states of pregnancy and lactation, due to the importance that thyroid hormones play in fetal neurodevelopment. Although the authors agree that all studies need further research on this topic to resolve the relationship between IE and thyroid disease, most of them express concern about potential health effects, advising a precautionary and integrated approach based on of primary prevention activities, through screening campaigns, health education and the reduction or elimination of these substances, in cooperation with regulatory bodies of international law, as suggested in the conference in Stockholm. The results of this study suggest the need for and the elements for a compelling collaboration between medical research, prevention and international law, with the aim of creating a new, more comprehensive approach to diseases that have as a contributing cause complex environmental factors. In these cases, it appears necessary to combine the latest scientific evidence with a national and supranational commitment to reducing the origin of hazardous chemicals in order to achieve effective relief of integrated prevention.
Translated title of the contribution[Autom. eng. transl.] Endocrine disruptors and thyroid: it's time for integrated prevention to reduce environmental risk factors
Original languageItalian
Title of host publicationAtti del 46° Congresso Nazionale SItI
Publication statusPublished - 2013
Event46° Congresso Nazionale SItI - Taormina
Duration: 17 Oct 201320 Oct 2013


Conference46° Congresso Nazionale SItI


  • Interferenti endocrini
  • Revisione sistematica


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