Integrating a Comprehensive Cancer Genome Profiling into Clinical Practice: A Blueprint in an Italian Referral Center

Camilla Nero; Simona Duranti; Flavia Giacomini; Angelo Minucci; Luciano Giacò; Angelo Piermattei; Maurizio Genuardi; Tina Pasciuto; Andrea Urbani; Gennaro Daniele; Domenica Lorusso; Rosa Pignataro; Giampaolo Tortora; Nicola Normanno; Giovanni Scambia

doi:10.3390/jpm12101746

Integrating a Comprehensive Cancer Genome Profiling into Clinical Practice: A Blueprint in an Italian Referral Center

Camilla Nero, Simona Duranti, Flavia Giacomini, Angelo Minucci, Luciano Giacò, Angelo Piermattei, Maurizio Genuardi, Tina Pasciuto, Andrea Urbani, Gennaro Daniele, Domenica Lorusso, Rosa Pignataro, Giampaolo Tortora, Nicola Normanno, Giovanni Scambia

IRCCS Istituto nazionale tumori Fondazione Giovanni Pascale - Napoli

Research output: Contribution to journal › Article

Abstract

The implementation of cancer molecular characterization in clinical practice has improved prognostic re-definition, extending the eligibility to a continuously increasing number of targeted treatments. Broad molecular profiling technologies better than organ-based approaches are believed to serve such dynamic purposes. We here present the workflow our institution adopted to run a comprehensive cancer genome profiling in clinical practice. This article describes the workflow designed to make a comprehensive cancer genome profiling program feasible and sustainable in a large-volume referral hospital. Keywords: bioinformatics; cancer; comprehensive cancer genome profiling; genomics; target therapy.

Original language	English
Pages (from-to)	1746-1746
Number of pages	1
Journal	Journal of Personalized Medicine
Volume	2022
DOIs	https://doi.org/10.3390/jpm12101746
Publication status	Published - 2022

Keywords

Genome

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.3390/jpm12101746

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Nero, C., Duranti, S., Giacomini, F., Minucci, A., Giacò, L., Piermattei, A., Genuardi, M., Pasciuto, T., Urbani, A., Daniele, G., Lorusso, D., Pignataro, R., Tortora, G., Normanno, N., & Scambia, G. (2022). Integrating a Comprehensive Cancer Genome Profiling into Clinical Practice: A Blueprint in an Italian Referral Center. Journal of Personalized Medicine, 2022, 1746-1746. https://doi.org/10.3390/jpm12101746

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abstract = "The implementation of cancer molecular characterization in clinical practice has improved prognostic re-definition, extending the eligibility to a continuously increasing number of targeted treatments. Broad molecular profiling technologies better than organ-based approaches are believed to serve such dynamic purposes. We here present the workflow our institution adopted to run a comprehensive cancer genome profiling in clinical practice. This article describes the workflow designed to make a comprehensive cancer genome profiling program feasible and sustainable in a large-volume referral hospital. Keywords: bioinformatics; cancer; comprehensive cancer genome profiling; genomics; target therapy.",

keywords = "Genome, Genome",

author = "Camilla Nero and Simona Duranti and Flavia Giacomini and Angelo Minucci and Luciano Giac{\`o} and Angelo Piermattei and Maurizio Genuardi and Tina Pasciuto and Andrea Urbani and Gennaro Daniele and Domenica Lorusso and Rosa Pignataro and Giampaolo Tortora and Nicola Normanno and Giovanni Scambia",

year = "2022",

doi = "10.3390/jpm12101746",

language = "English",

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Nero, C, Duranti, S, Giacomini, F, Minucci, A, Giacò, L, Piermattei, A, Genuardi, M , Pasciuto, T , Urbani, A, Daniele, G, Lorusso, D, Pignataro, R, Tortora, G, Normanno, N & Scambia, G 2022, 'Integrating a Comprehensive Cancer Genome Profiling into Clinical Practice: A Blueprint in an Italian Referral Center', Journal of Personalized Medicine, vol. 2022, pp. 1746-1746. https://doi.org/10.3390/jpm12101746

TY - JOUR

T1 - Integrating a Comprehensive Cancer Genome Profiling into Clinical Practice: A Blueprint in an Italian Referral Center

AU - Nero, Camilla

AU - Duranti, Simona

AU - Giacomini, Flavia

AU - Minucci, Angelo

AU - Giacò, Luciano

AU - Piermattei, Angelo

AU - Genuardi, Maurizio

AU - Pasciuto, Tina

AU - Urbani, Andrea

AU - Daniele, Gennaro

AU - Lorusso, Domenica

AU - Pignataro, Rosa

AU - Tortora, Giampaolo

AU - Normanno, Nicola

AU - Scambia, Giovanni

PY - 2022

Y1 - 2022

N2 - The implementation of cancer molecular characterization in clinical practice has improved prognostic re-definition, extending the eligibility to a continuously increasing number of targeted treatments. Broad molecular profiling technologies better than organ-based approaches are believed to serve such dynamic purposes. We here present the workflow our institution adopted to run a comprehensive cancer genome profiling in clinical practice. This article describes the workflow designed to make a comprehensive cancer genome profiling program feasible and sustainable in a large-volume referral hospital. Keywords: bioinformatics; cancer; comprehensive cancer genome profiling; genomics; target therapy.

AB - The implementation of cancer molecular characterization in clinical practice has improved prognostic re-definition, extending the eligibility to a continuously increasing number of targeted treatments. Broad molecular profiling technologies better than organ-based approaches are believed to serve such dynamic purposes. We here present the workflow our institution adopted to run a comprehensive cancer genome profiling in clinical practice. This article describes the workflow designed to make a comprehensive cancer genome profiling program feasible and sustainable in a large-volume referral hospital. Keywords: bioinformatics; cancer; comprehensive cancer genome profiling; genomics; target therapy.

KW - Genome

UR - http://hdl.handle.net/10807/219745

U2 - 10.3390/jpm12101746

DO - 10.3390/jpm12101746

M3 - Article

SN - 2075-4426

VL - 2022

SP - 1746

EP - 1746

JO - Journal of Personalized Medicine

JF - Journal of Personalized Medicine

ER -

Integrating a Comprehensive Cancer Genome Profiling into Clinical Practice: A Blueprint in an Italian Referral Center

Abstract

Keywords

UN SDGs

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