Inhibition of prostate efferent neurotransmission by amikacin

Emilio Sacco, Pierfrancesco Bassi, Mario Gardi, Andrea Volpe, Angelo Totaro, Francesco Pinto, F Nigro, E Ragazzi

Research output: Contribution to journalArticle


It has been suggested that manipulation of the autonomic nerve supply to the prostate leads to loss of functional and structural integrity of the gland, and that these changes may be useful in treating prostatic diseases. This study investigates the effect of amikacin on prostate efferent neurotransmission in vitro, in both rat and human prostate samples.
Original languageEnglish
Pages (from-to)1330-1335
Number of pages6
Publication statusPublished - 2008


  • Adenosine Triphosphate
  • Aged
  • Amikacin
  • Animals
  • Anti-Bacterial Agents
  • Autonomic Nervous System
  • Carbachol
  • Cholinergic Agonists
  • Dose-Response Relationship, Drug
  • Electric Stimulation
  • Humans
  • Male
  • Muscle Contraction
  • Muscle, Smooth
  • Neurons, Efferent
  • Norepinephrine
  • Prostate
  • Prostatic Hyperplasia
  • Rats
  • Rats, Wistar
  • Serotonin


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