Influence of the amount of myocardium subtended by a stenosis on fractional flow reserve

Antonio Maria Leone; Alberto De Caterina; Eloisa Basile; Andrea Gardi; Domenico Laezza; Mario Attilio Mazzari; Rocco Mongiardo; Rajesh Kharbanda; Florim Cuculi; Italo Porto; Giampaolo Niccoli; Francesco Burzotta; Carlo Trani; Adrian Paul Banning; Antonio Giuseppe Rebuzzi; Filippo Crea

doi:10.1161/CIRCINTERVENTIONS.112.971101

Influence of the amount of myocardium subtended by a stenosis on fractional flow reserve

Antonio Maria Leone, Alberto De Caterina, Eloisa Basile, Andrea Gardi, Domenico Laezza, Mario Attilio Mazzari, Rocco Mongiardo, Rajesh Kharbanda, Florim Cuculi, Italo Porto, Giampaolo Niccoli, Francesco Burzotta, Carlo Trani, Adrian Paul Banning, Antonio Giuseppe Rebuzzi, Filippo Crea

John Radcliffe Hospital

Research output: Contribution to journal › Article

65 Citations (Scopus)

Abstract

Fractional flow reserve (FFR) specifically relates to the severity of a stenosis to the mass of tissue to be perfused. Accordingly, the larger the territory to be perfused, the greater the flow and the pressure gradient induced by maximal hyperemia. Although this notion may be considered intuitive, its unequivocal demonstration is still lacking. The aim of our study was to evaluate the influence of the amount of myocardium subtended to an intermediate stenosis on FFR, especially in relation to quantitative coronary angiography.

Original language	English
Pages (from-to)	29-36
Number of pages	8
Journal	CIRCULATION. CARDIOVASCULAR INTERVENTIONS
Volume	6
DOIs	https://doi.org/10.1161/CIRCINTERVENTIONS.112.971101
Publication status	Published - 2013

Keywords

Aged
Coronary Angiography
Coronary Stenosis
Disease Progression
Female
Fractional Flow Reserve, Myocardial
Heart Function Tests
Humans
Male
Middle Aged
Myocardial Stunning
Predictive Value of Tests

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10.1161/CIRCINTERVENTIONS.112.971101

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Leone, A. M., De Caterina, A., Basile, E., Gardi, A., Laezza, D., Mazzari, M. A., Mongiardo, R., Kharbanda, R., Cuculi, F., Porto, I., Niccoli, G., Burzotta, F., Trani, C., Banning, A. P., Rebuzzi, A. G., & Crea, F. (2013). Influence of the amount of myocardium subtended by a stenosis on fractional flow reserve. CIRCULATION. CARDIOVASCULAR INTERVENTIONS, 6, 29-36. https://doi.org/10.1161/CIRCINTERVENTIONS.112.971101

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title = "Influence of the amount of myocardium subtended by a stenosis on fractional flow reserve",

abstract = "Fractional flow reserve (FFR) specifically relates to the severity of a stenosis to the mass of tissue to be perfused. Accordingly, the larger the territory to be perfused, the greater the flow and the pressure gradient induced by maximal hyperemia. Although this notion may be considered intuitive, its unequivocal demonstration is still lacking. The aim of our study was to evaluate the influence of the amount of myocardium subtended to an intermediate stenosis on FFR, especially in relation to quantitative coronary angiography.",

keywords = "Aged, Coronary Angiography, Coronary Stenosis, Disease Progression, Female, Fractional Flow Reserve, Myocardial, Heart Function Tests, Humans, Male, Middle Aged, Myocardial Stunning, Predictive Value of Tests, Aged, Coronary Angiography, Coronary Stenosis, Disease Progression, Female, Fractional Flow Reserve, Myocardial, Heart Function Tests, Humans, Male, Middle Aged, Myocardial Stunning, Predictive Value of Tests",

author = "Leone, {Antonio Maria} and {De Caterina}, Alberto and Eloisa Basile and Andrea Gardi and Domenico Laezza and Mazzari, {Mario Attilio} and Rocco Mongiardo and Rajesh Kharbanda and Florim Cuculi and Italo Porto and Giampaolo Niccoli and Francesco Burzotta and Carlo Trani and Banning, {Adrian Paul} and Rebuzzi, {Antonio Giuseppe} and Filippo Crea",

year = "2013",

doi = "10.1161/CIRCINTERVENTIONS.112.971101",

language = "English",

volume = "6",

pages = "29--36",

journal = "CIRCULATION. CARDIOVASCULAR INTERVENTIONS",

issn = "1941-7632",

publisher = "Baltimore, MD : Lippincott Williams & Wilkins for the American Heart Association",

}

Leone, AM, De Caterina, A, Basile, E, Gardi, A, Laezza, D, Mazzari, MA, Mongiardo, R, Kharbanda, R, Cuculi, F, Porto, I, Niccoli, G, Burzotta, F , Trani, C, Banning, AP, Rebuzzi, AG & Crea, F 2013, 'Influence of the amount of myocardium subtended by a stenosis on fractional flow reserve', CIRCULATION. CARDIOVASCULAR INTERVENTIONS, vol. 6, pp. 29-36. https://doi.org/10.1161/CIRCINTERVENTIONS.112.971101

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AU - Leone, Antonio Maria

AU - De Caterina, Alberto

AU - Basile, Eloisa

AU - Gardi, Andrea

AU - Laezza, Domenico

AU - Mazzari, Mario Attilio

AU - Mongiardo, Rocco

AU - Kharbanda, Rajesh

AU - Cuculi, Florim

AU - Porto, Italo

AU - Niccoli, Giampaolo

AU - Burzotta, Francesco

AU - Trani, Carlo

AU - Banning, Adrian Paul

AU - Rebuzzi, Antonio Giuseppe

AU - Crea, Filippo

PY - 2013

Y1 - 2013

N2 - Fractional flow reserve (FFR) specifically relates to the severity of a stenosis to the mass of tissue to be perfused. Accordingly, the larger the territory to be perfused, the greater the flow and the pressure gradient induced by maximal hyperemia. Although this notion may be considered intuitive, its unequivocal demonstration is still lacking. The aim of our study was to evaluate the influence of the amount of myocardium subtended to an intermediate stenosis on FFR, especially in relation to quantitative coronary angiography.

AB - Fractional flow reserve (FFR) specifically relates to the severity of a stenosis to the mass of tissue to be perfused. Accordingly, the larger the territory to be perfused, the greater the flow and the pressure gradient induced by maximal hyperemia. Although this notion may be considered intuitive, its unequivocal demonstration is still lacking. The aim of our study was to evaluate the influence of the amount of myocardium subtended to an intermediate stenosis on FFR, especially in relation to quantitative coronary angiography.

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KW - Coronary Angiography

KW - Coronary Stenosis

KW - Disease Progression

KW - Female

KW - Fractional Flow Reserve, Myocardial

KW - Heart Function Tests

KW - Humans

KW - Male

KW - Middle Aged

KW - Myocardial Stunning

KW - Predictive Value of Tests

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KW - Coronary Angiography

KW - Coronary Stenosis

KW - Disease Progression

KW - Female

KW - Fractional Flow Reserve, Myocardial

KW - Heart Function Tests

KW - Humans

KW - Male

KW - Middle Aged

KW - Myocardial Stunning

KW - Predictive Value of Tests

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DO - 10.1161/CIRCINTERVENTIONS.112.971101

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JO - CIRCULATION. CARDIOVASCULAR INTERVENTIONS

JF - CIRCULATION. CARDIOVASCULAR INTERVENTIONS

ER -

Influence of the amount of myocardium subtended by a stenosis on fractional flow reserve

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Keywords

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