Influence of environmental iodine deficiency on neonatal thyroid screening results

Rita Paola Maria Luciano, Laura Donati, Costantino Romagnoli, M Carta Sorcini, A Diodato, C Fazzini, G Sabini, S Carta, Me Grandolfo, Maria Grazia Vasta, J Locatelli De Maestri, P Bourdoux, F. Delange

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

During a multicentric pilot screening program for congenital hypothyroidism a comparison between the results obtained from Urbino, an area characterized by low iodine supply and endemic goiter, and Rome, a non-endemic area, has been made. The evaluation of neonatal urinary iodine excretion in the two areas showed significantly lower iodine urinary excretion levels in Urbino than in Rome. A shift of TSH at screening toward higher values as well as a higher percentage of recall in Urbino area than in Rome was observed. This finding, which well correlates with a low environmental iodine supply, emphasizes the importance of screening for congenital hypothyroidism as a suitable index of the presence and action of goitrogenic factors in the environment.
Original languageEnglish
Pages (from-to)309-312
Number of pages4
JournalJournal of Endocrinological Investigation
Volume11
Publication statusPublished - 1988

Keywords

  • Child, Preschool
  • Congenital Hypothyroidism
  • Environmental Exposure
  • Follow-Up Studies
  • Goiter, Endemic
  • Humans
  • Hypothyroidism
  • Infant, Newborn
  • Iodine
  • Italy
  • Mass Screening
  • Thyroid Function Tests
  • Thyrotropin
  • Thyroxine

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