Inflammatory fibroid polyp of the gallbladder bearing a platelet-derived growth factor receptor alpha mutation

Maurizio Martini, Pietro Familiari, Guido Costamagna, Riccardo Ricci, Luisa Santoro

Research output: Contribution to journalArticle

13 Citations (Scopus)


The inflammatory fibroid polyp (IFP) is a benign lesion occurring in the digestive tract, mostly in the stomach and small bowel, composed of fibrovascular tissue infiltrated by inflammatory cells including eosinophils and mastocytes. Its pathogenesis has been controversial (reactive versus neoplastic). The recent finding of mutations in platelet-derived growth factor receptor α (PDGFRA) in most gastric and small intestinal IFPs supported their neoplastic etiology, moreover helping in their differential diagnosis. In the only gallbladder IFP reported so far, the diagnosis was based on morphologic and immunohistochemical grounds, which in current standards would probably be considered not fully conclusive. Conversely, the gallbladder IFP we report shows typical pathologic features supported by a PDGFRA mutation, similar to its usual gastric and small intestinal counterparts, constituting the first report of an unequivocal IFP at gallbladder level. Thus, IFPs must be considered in the differential diagnosis of gallbladder mesenchymal masses, and genetic analysis of PDGFRA is a helpful tool for this purpose.
Original languageEnglish
Pages (from-to)721-724
Number of pages4
Publication statusPublished - 2013


  • Gallbladder Diseases
  • Polyps
  • Receptor, Platelet-Derived Growth Factor alpha


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