Infectious complications in neonatal transfusion: Narrative review and personal contribution

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Neonates and prematures are among the most transfused categories of patients. Adverse reactions due to transfusions, such as transfusion-transmitted infections, can affect the rest of their lives. In this systematic review, we revised the literature concerning transfusion-transmitted infection in neonates. We reported case-reports and case-series previously published and we integrated these data with our experience at local neonatal intensive care unit. Moreover, we illustrated strategies for mitigating transfusion-transmitted infections, including donor selection and testing, pathogen inactivation technologies and combined approaches, as for Cytomegalovirus infection, integrating leukoreduction and identification of seronegative donors.
Original languageEnglish
Pages (from-to)102951-N/A
JournalTransfusion and Apheresis Science
Publication statusPublished - 2020


  • Bacterial infections
  • Cytomegalovirus
  • Hepatitis
  • Neonatal transfusion


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