Increasing HPV vaccination uptake among adolescents: A systematic review

Anna Acampora, Adriano Grossi, Andrea Barbara, Vittoria Colamesta, Francesco Andrea Causio, Giovanna Elisa Calabro', Stefania Boccia, Chiara De Waure

Research output: Contribution to journalArticle


Human Papillomavirus (HPV) vaccination is a well-known fundamental strategy in the prevention of cervical cancer, as it is always caused by HPV infection. In fact, primary prevention of the infection corresponds to primary prevention of HPV-related cancers and other diseases. Since an effective prevention at the population level is the final goal, it is mandatory for healthcare systems to achieve a high HPV vaccination coverage among the adolescents to reduce the circulation of the virus and the burden of HPV-related diseases. This research identified, through a systematic literature review, 38 papers on strategies adopted to increase HPV vaccination coverage among adolescents. The evaluated strategies targeted adolescents/parents and/or healthcare providers and could be grouped in three main types: (1) reminder-based, (2) education, information, and communication activities, and (3) multicomponent strategies. Several types of strategy, such as those relied only on reminders and integrating different interventions, showed a positive impact on vaccination coverage. Nonetheless, the heterogeneity of the interventions suggests the importance to adapt such strategies to the specific national/local contexts to maximize vaccination coverage.
Original languageEnglish
Pages (from-to)1-14
Number of pages14
JournalInternational Journal of Environmental Research and Public Health
Publication statusPublished - 2020


  • Adolescent
  • Female
  • HPV vaccination
  • Health Personnel
  • Humans
  • Increasing coverage
  • Papillomavirus Infections
  • Papillomavirus Vaccines
  • Systematic review
  • Uterine Cervical Neoplasms
  • Vaccination
  • Vaccination Coverage


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