Increased prevalence of the G20210A prothrombin gene variant in acute coronary syndromes without metabolic or acquired risk factors or with limited extent of disease

Francesco Burzotta, Valerio De Stefano, Patrizia Chiusolo, Elena Rossi, Felicita Andreotti, Katia Paciaroni, Antonio Maria Leone, Maria Grazia Leone

Research output: Contribution to journalArticle

48 Citations (Scopus)

Abstract

Aims: To investigate the prevalence of the G20210A prothrombin and G1691A factor V gene variants in patients with acute coronary syndrome stratified according to risk factor profile and to extent of coronary disease, in comparison with matched healthy controls. Methods and Results: The 20210 prothrombin and the 1691 factor V loci were genotyped in 247 patients ≤65 years of age (190 myocardial infarction and 57 unstable angina as first presentation of disease) and in 247 healthy age- and sex-matched controls. The prevalence of the 1691A factor V allele was similar in cases and controls. The frequency of heterozygotes for the 20210A prothrombin allele was 6·5% among patients and 2·8% among controls (OR 2·4, 95% CI 1·0-5·9), increasing to 8·7% in patients with a family history of myocardial infarction (OR 3·3, 95% CI 1·2-9·1), to 9·9% in patients (n=81) with ≤1 vessel disease (OR 3·8, 95% CI 1·3-10·8), and to 13·0% in patients who were normocholesterolaemic, non-diabetic, normotensive and non-smokers (OR 5·1, 95% CI 1·2-21·4). Conclusions: These findings suggest that the 20210A prothrombin allele represents an inherited risk factor for acute coronary syndrome among patients who have limited extent of coronary disease at angiography or who lack major metabolic and acquired risk factors. © 2001 The European Society of Cardiology.
Original languageEnglish
Pages (from-to)26-30
Number of pages5
JournalEuropean Heart Journal
Volume23
DOIs
Publication statusPublished - 2002

Keywords

  • Acute Disease
  • Acute coronary syndrome
  • Aged
  • Alleles
  • Coronary Angiography
  • Coronary Disease
  • Factor V
  • Female
  • Genetic Variation
  • Genetic polymorphism
  • Humans
  • Italy
  • Male
  • Middle Aged
  • Myocardial Infarction
  • Prevalence
  • Prothrombin
  • Risk Factors
  • Risk factors
  • Syndrome

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