Increased forensic efficiency of a STR-based Y-specific haplotype by addition of the highly polymorphic DYS385 locus

A Caglià; Marina Dobosz; Ilaria Boschi; Ernesto D'Aloja; Vincenzo Lorenzo Pascali

Increased forensic efficiency of a STR-based Y-specific haplotype by addition of the highly polymorphic DYS385 locus

A Caglià, Marina Dobosz, Ilaria Boschi, Ernesto D'Aloja, Vincenzo Lorenzo Pascali

Research output: Contribution to journal › Article

Abstract

The polymorphic short tandem repeat (STR) locus DYS385 mapping to the male-specific region of human Y chromosome, was used to reinvestigate 125 unrelated Italian males, from our data archive, who had been previously typed for 7 different Y-specific STRs (DYS19, DYS389 I and II, DYS390, DYS391, DYS392, DYS393), defining a haplotype now widely adopted in the forensic context. The aim of this study was to improve the information value of the original haplotype in view of its application to issues of personal identification and parental analysis. DYS385 proved to be highly polymorphic (94.5% gene diversity) and the overall individualization capacity of the 8-loci haplotype was raised to 93.6%, with 117 unique assets out of 125 tested samples.

Original language	English
Pages (from-to)	142-146
Number of pages	5
Journal	International Journal of Legal Medicine
Volume	111
Publication status	Published - 1998

Keywords

DYS385
Short tandem repeats
Y-chromosome
Y-haplotype

Cite this

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title = "Increased forensic efficiency of a STR-based Y-specific haplotype by addition of the highly polymorphic DYS385 locus",

abstract = "The polymorphic short tandem repeat (STR) locus DYS385 mapping to the male-specific region of human Y chromosome, was used to reinvestigate 125 unrelated Italian males, from our data archive, who had been previously typed for 7 different Y-specific STRs (DYS19, DYS389 I and II, DYS390, DYS391, DYS392, DYS393), defining a haplotype now widely adopted in the forensic context. The aim of this study was to improve the information value of the original haplotype in view of its application to issues of personal identification and parental analysis. DYS385 proved to be highly polymorphic (94.5% gene diversity) and the overall individualization capacity of the 8-loci haplotype was raised to 93.6%, with 117 unique assets out of 125 tested samples.",

keywords = "DYS385, Short tandem repeats, Y-chromosome, Y-haplotype, DYS385, Short tandem repeats, Y-chromosome, Y-haplotype",

author = "A Cagli{\`a} and Marina Dobosz and Ilaria Boschi and Ernesto D'Aloja and Pascali, {Vincenzo Lorenzo}",

year = "1998",

language = "English",

volume = "111",

pages = "142--146",

journal = "International Journal of Legal Medicine",

issn = "0937-9827",

publisher = "Springer Verlag Germany:Tiergartenstrasse 17, D 69121 Heidelberg Germany:011 49 6221 3450, EMAIL: g.braun@springer.de, INTERNET: http://www.springer.de, Fax: 011 49 6221 345229",

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TY - JOUR

T1 - Increased forensic efficiency of a STR-based Y-specific haplotype by addition of the highly polymorphic DYS385 locus

AU - Caglià, A

AU - Dobosz, Marina

AU - Boschi, Ilaria

AU - D'Aloja, Ernesto

AU - Pascali, Vincenzo Lorenzo

PY - 1998

Y1 - 1998

N2 - The polymorphic short tandem repeat (STR) locus DYS385 mapping to the male-specific region of human Y chromosome, was used to reinvestigate 125 unrelated Italian males, from our data archive, who had been previously typed for 7 different Y-specific STRs (DYS19, DYS389 I and II, DYS390, DYS391, DYS392, DYS393), defining a haplotype now widely adopted in the forensic context. The aim of this study was to improve the information value of the original haplotype in view of its application to issues of personal identification and parental analysis. DYS385 proved to be highly polymorphic (94.5% gene diversity) and the overall individualization capacity of the 8-loci haplotype was raised to 93.6%, with 117 unique assets out of 125 tested samples.

AB - The polymorphic short tandem repeat (STR) locus DYS385 mapping to the male-specific region of human Y chromosome, was used to reinvestigate 125 unrelated Italian males, from our data archive, who had been previously typed for 7 different Y-specific STRs (DYS19, DYS389 I and II, DYS390, DYS391, DYS392, DYS393), defining a haplotype now widely adopted in the forensic context. The aim of this study was to improve the information value of the original haplotype in view of its application to issues of personal identification and parental analysis. DYS385 proved to be highly polymorphic (94.5% gene diversity) and the overall individualization capacity of the 8-loci haplotype was raised to 93.6%, with 117 unique assets out of 125 tested samples.

KW - DYS385

KW - Short tandem repeats

KW - Y-chromosome

KW - Y-haplotype

KW - DYS385

KW - Short tandem repeats

KW - Y-chromosome

KW - Y-haplotype

UR - http://hdl.handle.net/10807/10894

M3 - Article

SN - 0937-9827

VL - 111

SP - 142

EP - 146

JO - International Journal of Legal Medicine

JF - International Journal of Legal Medicine

ER -

Increased forensic efficiency of a STR-based Y-specific haplotype by addition of the highly polymorphic DYS385 locus

Abstract

Keywords

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