Increased FGF23 serum level is associated with unstable carotid plaque in type 2 diabetic subjects with internal carotid stenosis.

Federico Biscetti; Giuseppe Straface; Carlo Filippo Porreca; Giovanni Bertoletti; Claudio Vincenzoni; Francesco Snider; Egidio Stigliano; Vincenzo Arena; Flavia Angelini; Giovanni Pecorini; Antonio Bianchi; Raffaele Landolfi; Andrea Flex

doi:10.1186/s12933-015-0301-5

Increased FGF23 serum level is associated with unstable carotid plaque in type 2 diabetic subjects with internal carotid stenosis.

Federico Biscetti, Giuseppe Straface, Carlo Filippo Porreca, Giovanni Bertoletti, Claudio Vincenzoni, Francesco Snider, Egidio Stigliano, Vincenzo Arena, Flavia Angelini, Giovanni Pecorini, Antonio Bianchi, Raffaele Landolfi, Andrea Flex

St M. Goretti Hospital

Research output: Contribution to journal › Article › peer-review

12 Citations (Scopus)

Abstract

BACKGROUND: The object of this study was to investigate the potential role of FGF23 on plaque stability in type 2 diabetic patients with internal carotid artery stenosis. METHODS: In this retrospective observational study, we analyzed FGF23 serum level in 361 type 2 diabetic patients with internal carotid artery stenosis undergoing carotid endarterectomy and in 598 diabetic controls without carotid atherosclerosis. RESULTS: We found that FGF23 median serum levels was significantly higher in patients than in diabetic controls [67.7 (59.5-77.8) pg/mL and 43.89 (37.5-50.4), P < 0.001] and was significantly and independently associated with unstable plaque in patients with internal carotid artery stenosis [OR, 5,71 (95% CI, 2.09-15.29]. CONCLUSIONS: We have found, for the first time, that FGF23 could be associated with unstable plaque in type 2 diabetic patients with internal carotid artery stenosis.

Original language	English
Pages (from-to)	139-145
Number of pages	7
Journal	Cardiovascular Diabetology
Volume	2015
DOIs	https://doi.org/10.1186/s12933-015-0301-5
Publication status	Published - 2015

Keywords

FGF23
Internal carotid artery stenosis
OPG
Type 2 diabetes
Unstable Plaque

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1186/s12933-015-0301-5

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Biscetti, F., Straface, G., Porreca, C. F., Bertoletti, G., Vincenzoni, C., Snider, F., Stigliano, E., Arena, V., Angelini, F., Pecorini, G., Bianchi, A., Landolfi, R., & Flex, A. (2015). Increased FGF23 serum level is associated with unstable carotid plaque in type 2 diabetic subjects with internal carotid stenosis. Cardiovascular Diabetology, 2015, 139-145. https://doi.org/10.1186/s12933-015-0301-5

@article{a2be6d33605048acad211d30ef7f5a55,

title = "Increased FGF23 serum level is associated with unstable carotid plaque in type 2 diabetic subjects with internal carotid stenosis.",

abstract = "BACKGROUND: The object of this study was to investigate the potential role of FGF23 on plaque stability in type 2 diabetic patients with internal carotid artery stenosis. METHODS: In this retrospective observational study, we analyzed FGF23 serum level in 361 type 2 diabetic patients with internal carotid artery stenosis undergoing carotid endarterectomy and in 598 diabetic controls without carotid atherosclerosis. RESULTS: We found that FGF23 median serum levels was significantly higher in patients than in diabetic controls [67.7 (59.5-77.8) pg/mL and 43.89 (37.5-50.4), P < 0.001] and was significantly and independently associated with unstable plaque in patients with internal carotid artery stenosis [OR, 5,71 (95% CI, 2.09-15.29]. CONCLUSIONS: We have found, for the first time, that FGF23 could be associated with unstable plaque in type 2 diabetic patients with internal carotid artery stenosis.",

keywords = "FGF23, Internal carotid artery stenosis, OPG, Type 2 diabetes, Unstable Plaque, FGF23, Internal carotid artery stenosis, OPG, Type 2 diabetes, Unstable Plaque",

author = "Federico Biscetti and Giuseppe Straface and Porreca, {Carlo Filippo} and Giovanni Bertoletti and Claudio Vincenzoni and Francesco Snider and Egidio Stigliano and Vincenzo Arena and Flavia Angelini and Giovanni Pecorini and Antonio Bianchi and Raffaele Landolfi and Andrea Flex",

year = "2015",

doi = "10.1186/s12933-015-0301-5",

language = "English",

volume = "2015",

pages = "139--145",

journal = "Cardiovascular Diabetology",

issn = "1475-2840",

publisher = "London: BioMed Central.",

}

Biscetti, F, Straface, G, Porreca, CF, Bertoletti, G, Vincenzoni, C, Snider, F, Stigliano, E, Arena, V, Angelini, F, Pecorini, G , Bianchi, A, Landolfi, R & Flex, A 2015, 'Increased FGF23 serum level is associated with unstable carotid plaque in type 2 diabetic subjects with internal carotid stenosis.', Cardiovascular Diabetology, vol. 2015, pp. 139-145. https://doi.org/10.1186/s12933-015-0301-5

TY - JOUR

T1 - Increased FGF23 serum level is associated with unstable carotid plaque in type 2 diabetic subjects with internal carotid stenosis.

AU - Biscetti, Federico

AU - Straface, Giuseppe

AU - Porreca, Carlo Filippo

AU - Bertoletti, Giovanni

AU - Vincenzoni, Claudio

AU - Snider, Francesco

AU - Stigliano, Egidio

AU - Arena, Vincenzo

AU - Angelini, Flavia

AU - Pecorini, Giovanni

AU - Bianchi, Antonio

AU - Landolfi, Raffaele

AU - Flex, Andrea

PY - 2015

Y1 - 2015

N2 - BACKGROUND: The object of this study was to investigate the potential role of FGF23 on plaque stability in type 2 diabetic patients with internal carotid artery stenosis. METHODS: In this retrospective observational study, we analyzed FGF23 serum level in 361 type 2 diabetic patients with internal carotid artery stenosis undergoing carotid endarterectomy and in 598 diabetic controls without carotid atherosclerosis. RESULTS: We found that FGF23 median serum levels was significantly higher in patients than in diabetic controls [67.7 (59.5-77.8) pg/mL and 43.89 (37.5-50.4), P < 0.001] and was significantly and independently associated with unstable plaque in patients with internal carotid artery stenosis [OR, 5,71 (95% CI, 2.09-15.29]. CONCLUSIONS: We have found, for the first time, that FGF23 could be associated with unstable plaque in type 2 diabetic patients with internal carotid artery stenosis.

AB - BACKGROUND: The object of this study was to investigate the potential role of FGF23 on plaque stability in type 2 diabetic patients with internal carotid artery stenosis. METHODS: In this retrospective observational study, we analyzed FGF23 serum level in 361 type 2 diabetic patients with internal carotid artery stenosis undergoing carotid endarterectomy and in 598 diabetic controls without carotid atherosclerosis. RESULTS: We found that FGF23 median serum levels was significantly higher in patients than in diabetic controls [67.7 (59.5-77.8) pg/mL and 43.89 (37.5-50.4), P < 0.001] and was significantly and independently associated with unstable plaque in patients with internal carotid artery stenosis [OR, 5,71 (95% CI, 2.09-15.29]. CONCLUSIONS: We have found, for the first time, that FGF23 could be associated with unstable plaque in type 2 diabetic patients with internal carotid artery stenosis.

KW - FGF23

KW - Internal carotid artery stenosis

KW - OPG

KW - Type 2 diabetes

KW - Unstable Plaque

KW - FGF23

KW - Internal carotid artery stenosis

KW - OPG

KW - Type 2 diabetes

KW - Unstable Plaque

UR - http://hdl.handle.net/10807/70510

U2 - 10.1186/s12933-015-0301-5

DO - 10.1186/s12933-015-0301-5

M3 - Article

SN - 1475-2840

VL - 2015

SP - 139

EP - 145

JO - Cardiovascular Diabetology

JF - Cardiovascular Diabetology

ER -

Increased FGF23 serum level is associated with unstable carotid plaque in type 2 diabetic subjects with internal carotid stenosis.

Abstract

Keywords

UN SDGs

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