Increased expression of T-bet in circulating B cells from a patient with multiple sclerosis and celiac disease

Giovanni Frisullo, Viviana Nociti, Raffaele Iorio, Agata Katia Patanella, Alessandro Marti, Giovanni Cammarota, Massimiliano Mirabella, Anna Paola Batocchi

Research output: Contribution to journalArticlepeer-review

14 Citations (Scopus)

Abstract

Multiple sclerosis (MS) and celiac disease (CD) are considered to be T-cell-mediated autoimmune diseases. We describe a woman affected by a relapsing-remitting demyelinating disease of the central nervous system and occult CD (MS-CD), who showed during neurologic exacerbations a strong increased expression of T-bet, the key transcription factor for the development of Th1 cells, in circulating T, B cells and monocytes. Conversely, no difference of T-bet expression was observed in B cells from relapsing-remitting MS patients, either in relapse or in remission, and in controls. In the MS-CD patient, the interaction between MS- and CD-related inflammatory processes may result in an amplification of Th1 immune response
Original languageEnglish
Pages (from-to)837-839
Number of pages3
JournalHuman Immunology
Volume69
DOIs
Publication statusPublished - 2008

Keywords

  • celiac disease
  • multiple sclerosis

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