Abstract

A low count of CD4+ and CD8+ lymphocytes is a hallmark laboratory finding in the coronavirus disease 2019 (COVID-19). Using flow cytometry, we observed significantly higher CD95 (Fas) and PD-1 expression on both CD4+ T and CD8+ T cells in 42 COVID-19 patients when compared to controls. Higher CD95 expression in CD4+ cells correlated with lower CD4+ counts. A higher expression of CD95 in CD4+ and CD8+ lymphocytes correlated with a lower percentage of naive events. Our results might suggest a shift to antigen-activated T cells, expressing molecules increasing their propensity to apoptosis and exhaustion during COVID-19 infection.
Original languageEnglish
Pages (from-to)207-211
Number of pages5
JournalBritish Journal of Haematology
Volume191
DOIs
Publication statusPublished - 2020

Keywords

  • Adult
  • Aged
  • Aged, 80 and over
  • Aging
  • Apoptosis
  • CD4-Positive T-Lymphocytes
  • CD8-Positive T-Lymphocytes
  • CD95 (Fas)
  • COVID-19
  • Female
  • Humans
  • Lymphocyte Count
  • Lymphocyte Subsets
  • Lymphopenia
  • Male
  • Middle Aged
  • PD-1
  • Prognosis
  • Programmed Cell Death 1 Receptor
  • SARS-CoV-2
  • apoptosis
  • exhaustion
  • fas Receptor

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