In Vivo Emergence of Tigecycline Resistance in Multidrug-Resistant Klebsiella pneumoniae and Escherichia coli

Teresa Spanu, Giulia De Angelis, Tiziana D'Inzeo, Gabriele Sganga, Maria Celeste Cipriani, Barbara Pedruzzi, Maria Cataldo, Evelina Tacconelli

Research output: Contribution to journalArticle

Abstract

Although resistance to tigecycline has been reported in surveillance studies, a very few reports described the emergence of resistance in vivo. We report two cases of patients with infections due to SHV-12 producing Klebsiella pneumoniae and K. pneumoniae carbapenemase-3 (KPC-3) producing Escherichia coli, which developed tigecycline resistance in vivo after treatment. The reported limited experience underlines the risk of occurrence of tigecycline MIC increase under treatment pressure.
Original languageEnglish
Pages (from-to)4516-4518
Number of pages3
JournalAntimicrobial Agents and Chemotherapy
Volume2012
DOIs
Publication statusPublished - 2012

Keywords

  • resistance
  • tigecycline

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