In vivo Confocal Microscopy Report after Lasik with Sequential Accelerated Corneal Collagen Cross-Linking Treatment

Aldo Caporossi, Cosimo Mazzotta, Angelo Balestrazzi, Claudio Traversi, Stefano Caragiuli

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

We report the first pilot qualitative confocal microscopic analysis of a laser in situ keratomileusis (Lasik) treatment combined with sequential high-fluence accelerated corneal collagen cross-linking, denominated Lasik XTra, by means of HRT II laser scanning in vivo confocal microscopy after a 6-month follow-up. After obtaining approval from the Siena University Hospital Institutional Review Board, a 33-year-old female patient underwent a Lasik XTra procedure in her left eye. Confocal analysis demonstrated induced slight corneal microstructural changes by the interaction between UV-A, riboflavin and corneal stromal collagen, beyond the interface to a depth of 160 µm, without adverse events at the interface and endothelial levels. This application may be considered a prophylactic biomechanical treatment, stiffening the intermediate corneal stroma to prevent corneal ectasia and stabilizing the clinical results of refractive surgery. According to our preliminary experiences, this combined approach may be useful in higher-risk Lasik patients for hyperopic treatments, high myopia and lower corneal thicknesses.
Original languageEnglish
Pages (from-to)125-131
Number of pages7
JournalCase Reports in Ophthalmology
Volume5
DOIs
Publication statusPublished - 2014

Keywords

  • Accelerated corneal collagen cross-linking
  • Confocal microscopy
  • Laser in situ keratomileusis

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