TY - JOUR
T1 - -Improvement of mitochondrial function evaluated by ketoisocaproic acid breath test in patients with HCV infection undergoing albumin dialysis
AU - Zocco, Maria Assunta
AU - Di Campli, Cristiana
AU - Gaspari, Rita
AU - Candelli, Marcello
AU - Nista, Enrico Celestino
AU - Zileri Dal Verme, Lorenzo
AU - Di Gioacchino, Giorgia
AU - Santoliquido, Angelo
AU - Flore, Roberto Antonio
AU - Tondi, Paolo
AU - Proietti, Rodolfo
AU - Pola, Paolo
AU - Gasbarrini, Giovanni Battista
AU - Gasbarrini, Antonio
PY - 2005
Y1 - 2005
N2 - Abstract
BACKGROUND AND AIM: Oxidative injury occurs as a direct result of hepatitis C virus (HCV) core protein expression both in vitro and in vivo, and may be due to a direct effect on mitochondria. The ketoisocaproic acid (KICA) breath test is a simple, reliable, and noninvasive test to evaluate hepatic mitochondrial function. Albumin dialysis (MARS) is an effective bridge treatment for patients with acute failure superimposed on chronic liver disease. The aim of our study was to evaluate the improvement of mitochondrial function measured by KICA in patients undergoing MARS for acute-on-chronic HCV liver failure.
MATERIALS AND METHODS: Five patients with HCV chronic infection undergoing MARS treatment for acute decompensation were enrolled. Before and after each MARS treatment, patients underwent blood testing for the main hematochemical parameters as well as for mitochondrial function by the KICA breath test and the arterial ketone bodies ratio (AKBR).
RESULTS: MARS treatment effectively decreased the serum level of total bilirubin, bile acids, urea, and ammonium. Moreover, MARS treatment produced an increase in AKBR and in the cumulative percentage of (13)CO(2) recovered in exhaled air 2 hours after KICA ingestion.
CONCLUSION: Liver mitochondrial function appears to be beneficially affected by MARS treatment.
AB - Abstract
BACKGROUND AND AIM: Oxidative injury occurs as a direct result of hepatitis C virus (HCV) core protein expression both in vitro and in vivo, and may be due to a direct effect on mitochondria. The ketoisocaproic acid (KICA) breath test is a simple, reliable, and noninvasive test to evaluate hepatic mitochondrial function. Albumin dialysis (MARS) is an effective bridge treatment for patients with acute failure superimposed on chronic liver disease. The aim of our study was to evaluate the improvement of mitochondrial function measured by KICA in patients undergoing MARS for acute-on-chronic HCV liver failure.
MATERIALS AND METHODS: Five patients with HCV chronic infection undergoing MARS treatment for acute decompensation were enrolled. Before and after each MARS treatment, patients underwent blood testing for the main hematochemical parameters as well as for mitochondrial function by the KICA breath test and the arterial ketone bodies ratio (AKBR).
RESULTS: MARS treatment effectively decreased the serum level of total bilirubin, bile acids, urea, and ammonium. Moreover, MARS treatment produced an increase in AKBR and in the cumulative percentage of (13)CO(2) recovered in exhaled air 2 hours after KICA ingestion.
CONCLUSION: Liver mitochondrial function appears to be beneficially affected by MARS treatment.
KW - ketoisocaproic acid breath test
KW - ketoisocaproic acid breath test
UR - http://hdl.handle.net/10807/21207
M3 - Article
SN - 0041-1345
SP - 2554
EP - 2556
JO - Transplantation Proceedings
JF - Transplantation Proceedings
ER -
