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Impact of IL-18 on inflammation

  • Domenico Tripodi
  • , G Macauro
  • , A Anogeianaki
  • , M. L. Castellani
  • , Franco Pandolfi
  • , P Felaco
  • , E Toniato
  • , M. A. De Lutiis
  • , M. Fulcheri
  • , S. Tete
  • , R. Galzio
  • , V. Salini
  • , A. Caraffa
  • , P. Antinolfi
  • , I. Frydas
  • , G. Sabatino
  • , Y. B. Shaik Dasthagirisaheb

Research output: Contribution to journalArticle

Abstract

IL-18 is produced by many cell types, such as Kupffer cells, keratinocytes, macrophages, dendritic cells, and activated T cells stimulated by LPS. It is an important regulator of both innate and acquired immune responses. IL-18 plays a central role in rheumatoid arthritis since the T cells and macrophages that invade the synovial. These finding support a role for IL-18 in inflammation, allergy and immune diseases.
Original languageEnglish
Pages (from-to)7-11
Number of pages5
JournalJOURNAL OF BIOLOGICAL REGULATORS & HOMEOSTATIC AGENTS
Publication statusPublished - 2011

Keywords

  • Interleukin 18

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