Impact of drug-eluting stents and diabetes mellitus in patients with coronary bifurcation lesions: A survey from the italian society of invasive cardiology

Davide Capodanno, Corrado Tamburino, Giuseppe M. Sangiorgi, Enrico Romagnoli, Elisa Romagnoli, Antonio Colombo, Francesco Burzotta, Gabriele L. Gasparini, Leonardo Bolognese, Leonardo Paloscia, Paolo Rubino, Pasquale Rubino, Gennaro Sardella, Carlo Briguori, Federica Ettori, Gianfranco Franco, Franco Glieca, Domenico Di Girolamo, Imad Sheiban, Luigi PiattiCesare Greco, Anna Sonia Petronio, Bruno Loi, Ernesto Lyoi, Alberto Benassi, Aldo Patti, Achille Gaspardone, Stefano De Servi

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6 Citations (Scopus)

Abstract

Background-We investigated the long-term impact of different stent types and diabetes mellitus (DM) in patients undergoing percutaneous coronary intervention (PCI) of bifurcation lesions, based on a large multicenter survey endorsed by the Italian Society of Invasive Cardiology. Methods and Results-Relative benefits of drug eluting stent (DES) over bare metal stent (BMS) in patients with (n=1049) and without (n=3020) DM were analyzed with extensive multivariable adjustment. At 3 years, stenting with DES was associated with lower adjusted risk of major adverse cardiac events (MACE, adjusted hazard ratio [HR] 0.27, 95% confidence interval [CI] 0.15 to 0.49, P<0.001), cardiac death, and target lesion revascularization in DM patients but failed to demonstrate any significant benefit in patients without DM. Conclusions-In a large observational registry with admitted potential for selection bias and residual confounding, DES in DM patients with coronary bifurcation lesions were associated with improved outcomes in terms of MACE, cardiac death, and repeat revascularization at long-term follow up. These figures were not replicated in non-DM subjects. © 2011 American Heart Association, Inc.
Original languageEnglish
Pages (from-to)72-79
Number of pages8
JournalCIRCULATION. CARDIOVASCULAR INTERVENTIONS.
Volume4
DOIs
Publication statusPublished - 2011

Keywords

  • Aged
  • Angioplasty
  • Bifurcations
  • Coronary Artery Disease
  • Diabetes Mellitus
  • Diabetes mellitus
  • Diabetic Angiopathies
  • Drug-Eluting Stents
  • Female
  • Humans
  • Male
  • Middle Aged
  • Percutaneous coronary intervention
  • Treatment Outcome

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