Impact of aspirin on takotsubo syndrome: a propensity score-based analysis of the InterTAK Registry

Leonarda Galiuto, Filippo Crea, Francesca D'Ascenzo, Fabrizio D'Ascenzo, Sebastiano Gili, Maurizio Bertaina, Mario Iannaccone, Victoria L. Cammann, Davide Di Vece, Ken Kato, Andrea Saglietto, Konrad A. Szawan, Antonio H. Frangieh, Beatrice Boffini, Margherita Annaratone, Annahita Sarcon, Rena A. Levinson, Jennifer Franke, L. Christian Napp, Milosz JaguszewskiMichel Noutsias, Thomas Münzel, Maike Knorr, Susanne Heiner, Hugo A. Katus, Christof Burgdorf, Heribert Schunkert, Holger Thiele, Johann Bauersachs, Carsten Tschöpe, Burkert M. Pieske, Lawrence Rajan, Guido Michels, Roman Pfister, Alessandro Cuneo, Claudius Jacobshagen, Gerd Hasenfuß, Mahir Karakas, Wolfgang Koenig, Wolfgang Rottbauer, Samir M. Said, Ruediger C. Braun-Dullaeus, Adrian Banning, Florim Cuculi, Richard Kobza, Thomas A. Fischer, Tuija Vasankari, K.E. Juhani Airaksinen, Grzegorz Opolski, Rafal Dworakowski, Philip Maccarthy, Christoph Kaiser, Wolfgang Dichtl, Wolfgang M. Franz, Klaus Empen, Stephan B. Felix, Clément Delmas, Olivier Lairez, Ibrahim El-Battrawy, Ibrahim Akin, Martin Borggrefe, John D. Horowitz, Martin Kozel, Petr Tousek, Petr Widimský, Ekaterina Gilyarova, Alexandra Shilova, Mikhail Gilyarov, David E. Winchester, Christian Ukena, Michael Neuhaus, Jeroen J. Bax, Abhiram Prasad, Carlo Di Mario, Michael Böhm, Mauro Gasparini, Frank Ruschitzka, Eduardo Bossone, Rodolfo Citro, Mauro Rinaldi, Gaetano Maria De Ferrari, Thomas Lüscher, Jelena R. Ghadri, Christian Templin

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Aims: The aim of the present study was to investigate the impact of aspirin on prognosis in takotsubo syndrome (TTS). Methods and results: Patients from the International Takotsubo (InterTAK) Registry were categorized into two groups based on aspirin prescription at discharge. A comparison of clinical outcomes between groups was performed using an adjusted analysis with propensity score (PS) stratification; results from the unadjusted analysis were also reported to note the effect of the PS adjustment. Major adverse cardiac and cerebrovascular events (MACCE: a composite of death, myocardial infarction, TTS recurrence, stroke or transient ischaemic attack) were assessed at 30-day and 5-year follow-up. A total of 1533 TTS patients with known status regarding aspirin prescription at discharge were included. According to the adjusted analysis based on PS stratification, aspirin was not associated with a lower hazard of MACCE at 30-day [hazard ratio (HR) 1.24, 95% confidence interval (CI) 0.50–3.04, P = 0.64] or 5-year follow-up (HR 1.11, 95% CI 0.78–1.58, P = 0.58). These results were confirmed by sensitivity analyses performed with alternative PS-based methods, i.e. covariate adjustment and inverse probability of treatment weighting. Conclusion: In the present study, no association was found between aspirin use in TTS patients and a reduced risk of MACCE at 30-day and 5-year follow-up. These findings should be confirmed in adequately powered randomized controlled trials. ClinicalTrials.gov Identifier: NCT01947621.
Original languageEnglish
Pages (from-to)330-337
Number of pages8
JournalEuropean Journal of Heart Failure
Volume22
DOIs
Publication statusPublished - 2020

Keywords

  • Acute heart failure
  • Aspirin
  • Medical therapy
  • Outcome
  • Takotsubo syndrome

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