[Immunogenetic and functional study of first-degree relatives of patients with type I diabetes mellitus for identifying prediabetic subjects]

Translated title of the contribution: [Autom. eng. transl.] [Immunogenetic and functional study of first-degree relatives of patients with type I diabetes mellitus for identifying prediabetic subjects]

Salvatore Maria Corsello, Giovanni Gambassi, Raffaele Manna, Laura De Marinis Grasso, Flavia Scuderi, Carlo Antonio Rota, Antonino Barbarino, A Migliore, Ls Martin

Research output: Contribution to journalArticle

Abstract

Insulin dependent diabetes mellitus is an autoimmune disease with HLA-related genetic susceptibility. There is a latent phase before overt disease. During this phase islet cell antibodies (ICA) as a marker of humoral autoimmunity are detected and i.v. glucose tolerance test (IVGTT) is decreased. The aim of our work was to correlate IVGTT, HLA typing and ICA testing in all siblings of IDDM patients in order to identify high risk subjects (HRS). IVGTT showed significantly lower insulin levels in siblings vs controls (P less than 0.0001). This phenomenon could be caused by HLA unrelated genetic predisposition to low insulin secretion. Insulin level values of ICA+ siblings were lower than those of ICA- siblings, even if the difference was not significant.
Translated title of the contribution[Autom. eng. transl.] [Immunogenetic and functional study of first-degree relatives of patients with type I diabetes mellitus for identifying prediabetic subjects]
Original languageItalian
Pages (from-to)109-115
Number of pages7
JournalLA CLINICA TERAPEUTICA
Volume132
Publication statusPublished - 1990

Keywords

  • Autoantibodies
  • Consanguinity
  • Diabetes Mellitus, Type 1
  • Family Health
  • Glucose Tolerance Test
  • Humans
  • Insulin
  • Risk Factors
  • Time Factors

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