Immune response to influenza A (H1N1)v monovalent MF59-adjuvanted vaccine in HIV-infected patients

Massimiliano Fabbiani; Simona Di Giambenedetto; Michela Sali; Salvatore Farina; Paola Sansonetti; Enrica Tamburrini; Lorenzo Zileri Dal Verme; Giovanni Delogu; Andrea De Luca; David Kelvin; Roberto Cauda; Giovanni Fadda

doi:10.1016/j.vaccine.2011.02.020

Immune response to influenza A (H1N1)v monovalent MF59-adjuvanted vaccine in HIV-infected patients

Massimiliano Fabbiani
, Simona Di Giambenedetto
, Michela Sali^*
, Salvatore Farina
, Paola Sansonetti
, Enrica Tamburrini
, Lorenzo Zileri Dal Verme
, Giovanni Delogu
, Andrea De Luca
, David Kelvin
, Roberto Cauda
, Giovanni Fadda

^*Corresponding author

University Health Network University of Toronto
Azienda Ospedaliera Universitaria Senese

Research output: Contribution to journal › Article

27 Citations (Scopus)

Abstract

Immunogenicity of influenza A (H1N1)v MF59-adjuvanted vaccine was studied in HIV-infected patients. The vaccine was effective in inducing a protective immune response in patients with a CD4 >200. cells/Î¼L while individuals with CD4 <200. cells/Î¼L showed lower rates of seroconversion and seroprotection. These results underscore the usefulness of immunization against influenza in HIV-infected patients, though a boosting dose of vaccine may be required in seriously immunocompromised patients. Â© 2011 Elsevier Ltd.

Original language	English
Pages (from-to)	2836-2839
Number of pages	4
Journal	Vaccine
Volume	29
Issue number	16
DOIs	https://doi.org/10.1016/j.vaccine.2011.02.020
Publication status	Published - 2011

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

All Science Journal Classification (ASJC) codes

Molecular Medicine
General Immunology and Microbiology
General Veterinary
Public Health, Environmental and Occupational Health
Infectious Diseases

Keywords

Adjuvants
Adult
Antibodies
CD4 Lymphocyte Count
Environmental and Occupational Health
Female
H1N1 Subtype
HIV
HIV Infections
Hemagglutinin Glycoproteins
Human
Humans
Immunogenicity
Immunologic
Immunology and Microbiology (all)
Infectious Diseases
Influenza
Influenza A (H1N1)
Influenza A Virus
Influenza Vaccines
Influenza Virus
Male
Middle Aged
Molecular Medicine
Polysorbates
Public Health
Squalene
Swine flu
Vaccination
Veterinary (all)
Viral

Access to Document

10.1016/j.vaccine.2011.02.020

Cite this

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title = "Immune response to influenza A (H1N1)v monovalent MF59-adjuvanted vaccine in HIV-infected patients",

abstract = "Immunogenicity of influenza A (H1N1)v MF59-adjuvanted vaccine was studied in HIV-infected patients. The vaccine was effective in inducing a protective immune response in patients with a CD4 >200. cells/{\^I}¼L while individuals with CD4 <200. cells/{\^I}¼L showed lower rates of seroconversion and seroprotection. These results underscore the usefulness of immunization against influenza in HIV-infected patients, though a boosting dose of vaccine may be required in seriously immunocompromised patients. {\^A}{\textcopyright} 2011 Elsevier Ltd.",

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author = "Massimiliano Fabbiani and \{Di Giambenedetto\}, Simona and Michela Sali and Salvatore Farina and Paola Sansonetti and Enrica Tamburrini and Verme, \{Lorenzo Zileri Dal\} and Giovanni Delogu and \{De Luca\}, Andrea and David Kelvin and Roberto Cauda and Giovanni Fadda",

year = "2011",

doi = "10.1016/j.vaccine.2011.02.020",

language = "English",

volume = "29",

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AU - Fabbiani, Massimiliano

AU - Di Giambenedetto, Simona

AU - Sali, Michela

AU - Farina, Salvatore

AU - Sansonetti, Paola

AU - Tamburrini, Enrica

AU - Verme, Lorenzo Zileri Dal

AU - Delogu, Giovanni

AU - De Luca, Andrea

AU - Kelvin, David

AU - Cauda, Roberto

AU - Fadda, Giovanni

PY - 2011

Y1 - 2011

N2 - Immunogenicity of influenza A (H1N1)v MF59-adjuvanted vaccine was studied in HIV-infected patients. The vaccine was effective in inducing a protective immune response in patients with a CD4 >200. cells/Î¼L while individuals with CD4 <200. cells/Î¼L showed lower rates of seroconversion and seroprotection. These results underscore the usefulness of immunization against influenza in HIV-infected patients, though a boosting dose of vaccine may be required in seriously immunocompromised patients. Â© 2011 Elsevier Ltd.

AB - Immunogenicity of influenza A (H1N1)v MF59-adjuvanted vaccine was studied in HIV-infected patients. The vaccine was effective in inducing a protective immune response in patients with a CD4 >200. cells/Î¼L while individuals with CD4 <200. cells/Î¼L showed lower rates of seroconversion and seroprotection. These results underscore the usefulness of immunization against influenza in HIV-infected patients, though a boosting dose of vaccine may be required in seriously immunocompromised patients. Â© 2011 Elsevier Ltd.

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KW - Antibodies

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KW - Environmental and Occupational Health

KW - Female

KW - H1N1 Subtype

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KW - HIV Infections

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U2 - 10.1016/j.vaccine.2011.02.020

DO - 10.1016/j.vaccine.2011.02.020

M3 - Article

SN - 0264-410X

VL - 29

SP - 2836

EP - 2839

JO - Vaccine

JF - Vaccine

IS - 16

ER -

Immune response to influenza A (H1N1)v monovalent MF59-adjuvanted vaccine in HIV-infected patients

Abstract

UN SDGs

All Science Journal Classification (ASJC) codes

Keywords

Access to Document

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