IL-6 regulates MCP-1, ICAM-1 and IL-6 expression in human myoblasts.

Mariapaola Marino, Carlo Provenzano, Flavia Scuderi, Emanuela Bartoccioni, J Scheller, S Rose John

Research output: Contribution to journalArticlepeer-review

25 Citations (Scopus)


The inflammatory reaction in autoimmune polymyositis and rejection of transplanted myoblasts is characterized by mononuclear cell infiltration. In other settings monocytes are locally recruited by an IL-6-induced IL-8-to-MCP-1 switch. IL-6, upon binding to soluble gp80 (sIL-6R), can interact with membrane-bound ubiquitously expressed gp130 and activate virtually all cells (transsignaling). We found that human myoblasts could use transsignaling to produce IL-6, MCP-1 and ICAM-1; the addition of sIL-6R, binding to IL-1beta-induced IL-6, greatly increases IL-6 production. These in vitro data support the hypothesis that locally secreted IL-6 can target monocyte chemotaxis and leukocytes trafficking through an IL-6, MCP-1 and ICAM-1 modulation.
Original languageEnglish
Pages (from-to)41-48
Number of pages8
JournalJournal of Neuroimmunology
Publication statusPublished - 2008


  • IL-6
  • Muscle
  • trans-signaling


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