IL-6, monocyte infiltration and parenchymal cells

Mariapaola Marino, Carlo Provenzano, Emanuela Bartoccioni, Flavia Scuderi, Gilles Kaplanski, Valérie Marin, Catherine Farnarier

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

The January issue of Trends in Immunology contained an interesting article by Kaplanski et al., in which the authors observed that interleukin-6 (IL-6) acts as a switch, regulating the transition from neutrophil to monocyte involvement during the inflammatory response [1]. In this model, activated polymorphonuclear (PMN) cells release soluble interleukin-6 receptor a (sIL-6Ra), which, upon binding of locally produced IL-6, combines with glycoprotein 130 (gp130) on endothelial cells, enabling them to switch from IL-8 (neutrophil-recruiting) to monocyte chemotactic protein-1 (monocyte-recruiting) secretion
Original languageEnglish
Pages (from-to)298-299
Number of pages2
JournalTrends in Immunology
Volume24
DOIs
Publication statusPublished - 2003

Keywords

  • Animals
  • Cell Movement
  • Humans
  • Inflammation
  • Interleukin-6
  • Monocytes
  • Neutrophils
  • Signal Transduction

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