IGHV gene mutational status and 17p deletion are independent molecular predictors in a comprehensive clinical-biological prognostic model for overall survival prediction in chronic lymphocytic leukemia

P Bulian; D Rossi; F Forconi; G Del Poeta; F Bertoni; E Zucca; M Montillo; G Pozzato; G D'Arena; Dg Efremov; R Marasca; F Lauria; G Gaidano; V Gattei; Luca Laurenti

doi:10.1186/1479-5876-10-18

IGHV gene mutational status and 17p deletion are independent molecular predictors in a comprehensive clinical-biological prognostic model for overall survival prediction in chronic lymphocytic leukemia

P Bulian^*
, D Rossi
, F Forconi
, G Del Poeta
, F Bertoni
, E Zucca
, M Montillo
, G Pozzato
, G D'Arena
, Dg Efremov
, R Marasca
, F Lauria
, G Gaidano
, V Gattei
, Luca Laurenti

^*Corresponding author

Research output: Contribution to journal › Article

17 Citations (Scopus)

Abstract

Prognostic index for survival estimation by clinical-demographic variables were previously proposed in chronic lymphocytic leukemia (CLL) patients. Our objective was to test in a large retrospective cohort of CLL patients the prognostic power of biological and clinical-demographic variable in a comprehensive multivariate model. A new prognostic index was proposed.

Original language	English
Pages (from-to)	18-18
Number of pages	1
Journal	Journal of Translational Medicine
Volume	10
Issue number	n/A
DOIs	https://doi.org/10.1186/1479-5876-10-18
Publication status	Published - 2012

All Science Journal Classification (ASJC) codes

General Biochemistry,Genetics and Molecular Biology

Keywords

80 and over
Adult
Aged
B-Cell
Biological
Chromosome Deletion
Chromosomes
Chronic
Cohort Studies
Female
Genes
Human
Humans
Immunoglobulin Heavy Chain
Kaplan-Meier Estimate
Leukemia
Lymphocytic
Male
Middle Aged
Models
Multivariate Analysis
Mutation
Nomograms
Pair 17
Proportional Hazards Models
Reproducibility of Results
Time Factors
Young Adult

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10.1186/1479-5876-10-18

Cite this

Bulian, P., Rossi, D., Forconi, F., Del Poeta, G., Bertoni, F., Zucca, E., Montillo, M., Pozzato, G., D'Arena, G., Efremov, D., Marasca, R., Lauria, F., Gaidano, G., Gattei, V., & Laurenti, L. (2012). IGHV gene mutational status and 17p deletion are independent molecular predictors in a comprehensive clinical-biological prognostic model for overall survival prediction in chronic lymphocytic leukemia. Journal of Translational Medicine, 10(n/A), 18-18. https://doi.org/10.1186/1479-5876-10-18

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title = "IGHV gene mutational status and 17p deletion are independent molecular predictors in a comprehensive clinical-biological prognostic model for overall survival prediction in chronic lymphocytic leukemia",

abstract = "Prognostic index for survival estimation by clinical-demographic variables were previously proposed in chronic lymphocytic leukemia (CLL) patients. Our objective was to test in a large retrospective cohort of CLL patients the prognostic power of biological and clinical-demographic variable in a comprehensive multivariate model. A new prognostic index was proposed.",

keywords = "80 and over, Adult, Aged, B-Cell, Biological, Chromosome Deletion, Chromosomes, Chronic, Cohort Studies, Female, Genes, Human, Humans, Immunoglobulin Heavy Chain, Kaplan-Meier Estimate, Leukemia, Lymphocytic, Male, Middle Aged, Models, Multivariate Analysis, Mutation, Nomograms, Pair 17, Proportional Hazards Models, Reproducibility of Results, Time Factors, Young Adult, 80 and over, Adult, Aged, B-Cell, Biological, Chromosome Deletion, Chromosomes, Chronic, Cohort Studies, Female, Genes, Human, Humans, Immunoglobulin Heavy Chain, Kaplan-Meier Estimate, Leukemia, Lymphocytic, Male, Middle Aged, Models, Multivariate Analysis, Mutation, Nomograms, Pair 17, Proportional Hazards Models, Reproducibility of Results, Time Factors, Young Adult",

author = "P Bulian and D Rossi and F Forconi and \{Del Poeta\}, G and F Bertoni and E Zucca and M Montillo and G Pozzato and G D'Arena and Dg Efremov and R Marasca and F Lauria and G Gaidano and V Gattei and Luca Laurenti",

year = "2012",

doi = "10.1186/1479-5876-10-18",

language = "English",

volume = "10",

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Bulian, P, Rossi, D, Forconi, F, Del Poeta, G, Bertoni, F, Zucca, E, Montillo, M, Pozzato, G, D'Arena, G, Efremov, D, Marasca, R, Lauria, F, Gaidano, G, Gattei, V & Laurenti, L 2012, 'IGHV gene mutational status and 17p deletion are independent molecular predictors in a comprehensive clinical-biological prognostic model for overall survival prediction in chronic lymphocytic leukemia', Journal of Translational Medicine, vol. 10, no. n/A, pp. 18-18. https://doi.org/10.1186/1479-5876-10-18

TY - JOUR

T1 - IGHV gene mutational status and 17p deletion are independent molecular predictors in a comprehensive clinical-biological prognostic model for overall survival prediction in chronic lymphocytic leukemia

AU - Bulian, P

AU - Rossi, D

AU - Forconi, F

AU - Del Poeta, G

AU - Bertoni, F

AU - Zucca, E

AU - Montillo, M

AU - Pozzato, G

AU - D'Arena, G

AU - Efremov, Dg

AU - Marasca, R

AU - Lauria, F

AU - Gaidano, G

AU - Gattei, V

AU - Laurenti, Luca

PY - 2012

Y1 - 2012

N2 - Prognostic index for survival estimation by clinical-demographic variables were previously proposed in chronic lymphocytic leukemia (CLL) patients. Our objective was to test in a large retrospective cohort of CLL patients the prognostic power of biological and clinical-demographic variable in a comprehensive multivariate model. A new prognostic index was proposed.

AB - Prognostic index for survival estimation by clinical-demographic variables were previously proposed in chronic lymphocytic leukemia (CLL) patients. Our objective was to test in a large retrospective cohort of CLL patients the prognostic power of biological and clinical-demographic variable in a comprehensive multivariate model. A new prognostic index was proposed.

KW - 80 and over

KW - Adult

KW - Aged

KW - B-Cell

KW - Biological

KW - Chromosome Deletion

KW - Chromosomes

KW - Chronic

KW - Cohort Studies

KW - Female

KW - Genes

KW - Human

KW - Humans

KW - Immunoglobulin Heavy Chain

KW - Kaplan-Meier Estimate

KW - Leukemia

KW - Lymphocytic

KW - Male

KW - Middle Aged

KW - Models

KW - Multivariate Analysis

KW - Mutation

KW - Nomograms

KW - Pair 17

KW - Proportional Hazards Models

KW - Reproducibility of Results

KW - Time Factors

KW - Young Adult

KW - 80 and over

KW - Adult

KW - Aged

KW - B-Cell

KW - Biological

KW - Chromosome Deletion

KW - Chromosomes

KW - Chronic

KW - Cohort Studies

KW - Female

KW - Genes

KW - Human

KW - Humans

KW - Immunoglobulin Heavy Chain

KW - Kaplan-Meier Estimate

KW - Leukemia

KW - Lymphocytic

KW - Male

KW - Middle Aged

KW - Models

KW - Multivariate Analysis

KW - Mutation

KW - Nomograms

KW - Pair 17

KW - Proportional Hazards Models

KW - Reproducibility of Results

KW - Time Factors

KW - Young Adult

UR - https://publicatt.unicatt.it/handle/10807/40269

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U2 - 10.1186/1479-5876-10-18

DO - 10.1186/1479-5876-10-18

M3 - Article

SN - 1479-5876

VL - 10

SP - 18

EP - 18

JO - Journal of Translational Medicine

JF - Journal of Translational Medicine

IS - n/A

ER -

IGHV gene mutational status and 17p deletion are independent molecular predictors in a comprehensive clinical-biological prognostic model for overall survival prediction in chronic lymphocytic leukemia

Abstract

All Science Journal Classification (ASJC) codes

Keywords

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