IGHV gene mutational status and 17p deletion are independent molecular predictors in a comprehensive clinical-biological prognostic model for overall survival prediction in chronic lymphocytic leukemia

Luca Laurenti, P Bulian, D Rossi, F Forconi, G Del Poeta, F Bertoni, E Zucca, M Montillo, G Pozzato, G D'Arena, Dg Efremov, R Marasca, F Lauria, G Gaidano, V Gattei

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17 Citations (Scopus)

Abstract

Prognostic index for survival estimation by clinical-demographic variables were previously proposed in chronic lymphocytic leukemia (CLL) patients. Our objective was to test in a large retrospective cohort of CLL patients the prognostic power of biological and clinical-demographic variable in a comprehensive multivariate model. A new prognostic index was proposed.
Original languageEnglish
Pages (from-to)18-18
Number of pages1
JournalJournal of Translational Medicine
Volume10
DOIs
Publication statusPublished - 2012

Keywords

  • Adult
  • Aged
  • Aged, 80 and over
  • Chromosome Deletion
  • Chromosomes, Human, Pair 17
  • Cohort Studies
  • Female
  • Genes, Immunoglobulin Heavy Chain
  • Humans
  • Kaplan-Meier Estimate
  • Leukemia, Lymphocytic, Chronic, B-Cell
  • Male
  • Middle Aged
  • Models, Biological
  • Multivariate Analysis
  • Mutation
  • Nomograms
  • Proportional Hazards Models
  • Reproducibility of Results
  • Time Factors
  • Young Adult

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