Identifying and addressing unmet clinical needs in Ph-neg classical myeloproliferative neoplasms: a consensus-based SIE, SIES, GITMO position paper

Valerio De Stefano, Giovanni Barosi, Alessandro M. Vannucchi, Fabrizio Pane, Francesco Passamonti, Alessandro Rambaldi, Giuseppe Saglio, Tiziano Barbui, Sante Tura

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23 Citations (Scopus)

Abstract

This article presents the results of group discussion among experts from SIE, SIES and GITMO societies aimed at highlighting unmet challenges in the management of Ph-neg myeloproliferative neoplasms (MPNs). The issues analyzed were: diagnosis of prefibrotic myelofibrosis; diagnosis of Ph-neg MPNs in the setting of splanchnic vein thrombosis (SVT); management of low-risk PV and low-risk ET patients with JAK2V617F mutation; molecular biomarkers in the prognostic evaluation of myelofibrosis (MF); ruxolitinib therapy in low-risk MF; therapy in patients with SVT-associated Ph-neg MPN; indications of splenectomy in MF. For each of these issues, proposals for advancement in clinical research were addressed.
Original languageEnglish
Pages (from-to)155-160
Number of pages6
JournalLeukemia Research
Volume38
DOIs
Publication statusPublished - 2014

Keywords

  • Consensus
  • Essential thrombocythemia
  • Expert Testimony
  • Myelofibrosis
  • Myeloproliferative Disorders
  • Myeloproliferative neoplasm
  • Unmet clinical need
  • polycythemia vera

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