Hypervascularity Predicts Complete Pathologic Response to Chemotherapy and Late Outcomes in Breast Cancer

Enida Bufi; Paolo Belli; Marialuisa Di Matteo; Michela Giuliani; Mariavalentina Tumino; Pierluigi Rinaldi; Luigia Nardone; Gianluca Franceschini; Antonino Mule'; Lorenzo Bonomo

doi:10.1016/j.clbc.2016.06.007

Hypervascularity Predicts Complete Pathologic Response to Chemotherapy and Late Outcomes in Breast Cancer

Enida Bufi^*
, Paolo Belli
, Marialuisa Di Matteo
, Michela Giuliani
, Mariavalentina Tumino
, Pierluigi Rinaldi
, Luigia Nardone
, Gianluca Franceschini
, Antonino Mule'
, Lorenzo Bonomo

^*Corresponding author

Research output: Contribution to journal › Article

4 Citations (Scopus)

Abstract

Micro-Abstract Asymmetric increase in breast vascularity (AIBV) is an emerging marker in magnetic resonance imaging-based evaluation of breast cancer. We analyze herein the largest series so far aimed at elucidating the potential role of AIBV in predicting the early and late outcomes of locally advanced breast cancer. We observed that, despite more aggressive pathologic profile of tumors associated with AIBV, they also present greater sensitivity to neoadjuvant chemotherapy. Nonetheless, the persistence of AIBV after neoadjuvant chemotherapy is associated with worse late prognosis and might be used to tailor additional treatments.

Original language	English
Pages (from-to)	e193-e201
Number of pages	9
Journal	Clinical Breast Cancer
Volume	16
Issue number	6
DOIs	https://doi.org/10.1016/j.clbc.2016.06.007
Publication status	Published - 2016

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

All Science Journal Classification (ASJC) codes

Oncology
Cancer Research

Keywords

Breast tumor
Cancer Research
Increased vascularization
Magnetic Resonance Imaging
Neoadjuvant chemotherapy
Oncology
Prognosis

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10.1016/j.clbc.2016.06.007

Cite this

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title = "Hypervascularity Predicts Complete Pathologic Response to Chemotherapy and Late Outcomes in Breast Cancer",

abstract = "Micro-Abstract Asymmetric increase in breast vascularity (AIBV) is an emerging marker in magnetic resonance imaging-based evaluation of breast cancer. We analyze herein the largest series so far aimed at elucidating the potential role of AIBV in predicting the early and late outcomes of locally advanced breast cancer. We observed that, despite more aggressive pathologic profile of tumors associated with AIBV, they also present greater sensitivity to neoadjuvant chemotherapy. Nonetheless, the persistence of AIBV after neoadjuvant chemotherapy is associated with worse late prognosis and might be used to tailor additional treatments.",

keywords = "Breast tumor, Cancer Research, Increased vascularization, Magnetic Resonance Imaging, Neoadjuvant chemotherapy, Oncology, Prognosis, Breast tumor, Cancer Research, Increased vascularization, Magnetic Resonance Imaging, Neoadjuvant chemotherapy, Oncology, Prognosis",

author = "Enida Bufi and Paolo Belli and \{Di Matteo\}, Marialuisa and Michela Giuliani and Mariavalentina Tumino and Pierluigi Rinaldi and Luigia Nardone and Gianluca Franceschini and Antonino Mule' and Lorenzo Bonomo",

year = "2016",

doi = "10.1016/j.clbc.2016.06.007",

language = "English",

volume = "16",

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publisher = "Elsevier Inc.",

number = "6",

}

TY - JOUR

T1 - Hypervascularity Predicts Complete Pathologic Response to Chemotherapy and Late Outcomes in Breast Cancer

AU - Bufi, Enida

AU - Belli, Paolo

AU - Di Matteo, Marialuisa

AU - Giuliani, Michela

AU - Tumino, Mariavalentina

AU - Rinaldi, Pierluigi

AU - Nardone, Luigia

AU - Franceschini, Gianluca

AU - Mule', Antonino

AU - Bonomo, Lorenzo

PY - 2016

Y1 - 2016

N2 - Micro-Abstract Asymmetric increase in breast vascularity (AIBV) is an emerging marker in magnetic resonance imaging-based evaluation of breast cancer. We analyze herein the largest series so far aimed at elucidating the potential role of AIBV in predicting the early and late outcomes of locally advanced breast cancer. We observed that, despite more aggressive pathologic profile of tumors associated with AIBV, they also present greater sensitivity to neoadjuvant chemotherapy. Nonetheless, the persistence of AIBV after neoadjuvant chemotherapy is associated with worse late prognosis and might be used to tailor additional treatments.

AB - Micro-Abstract Asymmetric increase in breast vascularity (AIBV) is an emerging marker in magnetic resonance imaging-based evaluation of breast cancer. We analyze herein the largest series so far aimed at elucidating the potential role of AIBV in predicting the early and late outcomes of locally advanced breast cancer. We observed that, despite more aggressive pathologic profile of tumors associated with AIBV, they also present greater sensitivity to neoadjuvant chemotherapy. Nonetheless, the persistence of AIBV after neoadjuvant chemotherapy is associated with worse late prognosis and might be used to tailor additional treatments.

KW - Breast tumor

KW - Cancer Research

KW - Increased vascularization

KW - Magnetic Resonance Imaging

KW - Neoadjuvant chemotherapy

KW - Oncology

KW - Prognosis

KW - Breast tumor

KW - Cancer Research

KW - Increased vascularization

KW - Magnetic Resonance Imaging

KW - Neoadjuvant chemotherapy

KW - Oncology

KW - Prognosis

UR - https://publicatt.unicatt.it/handle/10807/91621

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U2 - 10.1016/j.clbc.2016.06.007

DO - 10.1016/j.clbc.2016.06.007

M3 - Article

SN - 1526-8209

VL - 16

SP - e193-e201

JO - Clinical Breast Cancer

JF - Clinical Breast Cancer

IS - 6

ER -

Hypervascularity Predicts Complete Pathologic Response to Chemotherapy and Late Outcomes in Breast Cancer

Abstract

UN SDGs

All Science Journal Classification (ASJC) codes

Keywords

Access to Document

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