Hyperthermic intrathoracic chemotherapy combined to iterative cytoreductive surgery to treat a pleural carcinosis from psudomixoma peritonei. A case report

Filippo Lococo, Liliana Sollazzi, Stefano Margaritora, Amedeo Giuseppe Iaffaldano, Giovanni Schinzari, Diomira Tabacco, Paola Aceto, Carlo Abatini

Research output: Contribution to journalArticle

Abstract

Pseudomyxoma peritonei (PMP) is an uncommon disease with locally-invasive attitude. Intrathoracic spread is rarely reported and its management extremely challenging. A 51-year-old Caucasian female presented with left pleural carcinosis 9-months after two sequential abdominal surgical procedures combined with HIPEC for low-grade PMP. Cytoreductive surgery (pleurectomy/decortication) was followed by 60-minutes hyperthermic intrathoracic chemotherapy mitomycin-C (215 mg/ m2) infusing at same temperature (42°C) and intrapleural pression (2-4 mmH2O). No intra-operative complication occurred, the post-op stay was uneventful and no sign of recurrence was observed 9-months after surgery. Cytoreductive thoracic surgery and hyperthermic chemotherapy (HITHOC) could be a feasible therapeutic option in very selected cases.
Original languageEnglish
Pages (from-to)362-365
Number of pages4
JournalEuropean Review for Medical and Pharmacological Sciences
Volume25
DOIs
Publication statusPublished - 2021

Keywords

  • Chemotherapy
  • Hyperthermic
  • Intrathoracic chemotherapy
  • Psedomixoma

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