Human papillomavirus (HPV) infection in squamous cell carcinomas arising from the oropharynx: detection of HPV DNA and p16 immunohistochemistry as diagnostic and prognostic indicators--a pilot study

Michela Sali, Gian Franco Zannoni, Rosaria Santangelo, Giovanni Almadori, Jacopo Galli, Giovanni Delogu, Maurizio Sanguinetti, Guido Rindi, Vincenzo Valentini, Gaetano Paludetti, Francesco Bussu, Roberto Gallus, Gianluigi Petrone, Rosa Autorino, Nicola Dinapoli, Valerio Gaetano Vellone, Cristina Graziani, Francesco Micciche', Massimo Tommasino

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

Human papillomavirus (HPV) 16 infection is associated with oropharyngeal carcinogenesis and is likely the cause of the reported increase in disease incidence. We evaluated the prevalence of HPV infection and the reliability of different diagnostic tools using primary tumor samples from a cohort of 50 patients.
Original languageEnglish
Pages (from-to)1115-1120
Number of pages6
JournalInternational Journal of Radiation Oncology Biology Physics
Volume89
DOIs
Publication statusPublished - 2014

Keywords

  • Aged
  • Carcinoma, Squamous Cell
  • DNA, Viral
  • Female
  • Human papillomavirus 16
  • Humans
  • Male
  • Middle Aged
  • Oropharyngeal Neoplasms
  • Papillomavirus Infections
  • Paraffin Embedding
  • Pilot Projects
  • Prevalence
  • Prognosis
  • RNA, Viral
  • Reproducibility of Results

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