Human monoclonal antibody fragment specific for glycoprotein G in Herpes simplex type 2 with applications for serotype-specific diagnosis

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Abstract

A combinatorial library was used to select a human monoclonal antibody fragment (Fab) with high affinity for G glycoprotein in herpes simplex virus type 2 (HSV-2). Tests with 112 clinical specimens demonstrated successful discrimination between HSV-2 and HSV-1, showing the potential of Fab as a low-cost tool for HSV subtyping in clinical diagnosis.
Original languageEnglish
Pages (from-to)1250-1253
Number of pages4
JournalJournal of Clinical Microbiology
Publication statusPublished - 2004

Keywords

  • Glycoprotein G
  • Human recombinant antibodies
  • herpes simplex

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